A Compilation of the Diverse miRNA Functions in <i>Caenorhabditis elegans</i> and <i>Drosophila melanogaster</i> Development
MicroRNAs are critical regulators of post-transcriptional gene expression in a wide range of taxa, including invertebrates, mammals, and plants. Since their discovery in the nematode, <i>Caenorhabditis elegans,</i> miRNA research has exploded, and they are being identified in almost ever...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/8/6963 |
| Summary: | MicroRNAs are critical regulators of post-transcriptional gene expression in a wide range of taxa, including invertebrates, mammals, and plants. Since their discovery in the nematode, <i>Caenorhabditis elegans,</i> miRNA research has exploded, and they are being identified in almost every facet of development. Invertebrate model organisms, particularly <i>C. elegans,</i> and <i>Drosophila melanogaster</i>, are ideal systems for studying miRNA function, and the roles of many miRNAs are known in these animals. In this review, we compiled the functions of many of the miRNAs that are involved in the development of these invertebrate model species. We examine how gene regulation by miRNAs shapes both embryonic and larval development and show that, although many different aspects of development are regulated, several trends are apparent in the nature of their regulation. |
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| ISSN: | 1661-6596 1422-0067 |