Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol

Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol

Pain represents a primary symptom of numerous diseases and conditions, affecting millions of people worldwide. Effective analgesic medications can alleviate or eliminate pain, thereby enhancing patients’ quality of life and assisting them in resuming normal physical and social activities. However, s...

Full description

Bibliographic Details
Main Authors:	S. O. Fedotov, A. S. Hotsulia, Yu. V. Karpenko
Format:	Article
Language:	English
Published:	Zaporozhye State Medical University 2023-11-01
Series:	Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:	triazoles pyrazole synthesis properties
Online Access:	http://pharmed.zsmu.edu.ua/article/view/288364/284223

Similar Items

Synthesis and properties of S-alkyl 4-amino-5-(5-(3-fluorophenyl)-pyrazol-3-yl)-1,2,4-triazole-3-thiol derivatives
by: S. O. Fedotov, et al.
Published: (2023-04-01)

Synthesis, structure and properties of N-R-2-(5-(5-methyl-1H-pyrazole-3-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetamides
by: A. S. Hotsulia, et al.
Published: (2019-03-01)

Synthesis and properties of S-derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol
by: S. O. Fedotov, et al.
Published: (2021-12-01)

Synthesis and properties of 6-(2,6-dichlorophenyl)-3- (3-methyl-1H-pyrazol-5-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazine-7-carboxylic acid and its salts
by: S. O. Fedotov, et al.
Published: (2023-07-01)

Synthesis and properties of some 3-(5-(4-methoxyphenyl)pyrazol-3-yl)-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles
by: S. O. Fedotov, et al.
Published: (2022-08-01)

Analgesic Activity of Some 1,2,4-Triazole Heterocycles Clubbed with Pyrazole, Tetrazole, Isoxazole and Pyrimidine
by: Ramdas Bhanudas Pandhare, et al.
Published: (2013-02-01)

Synthesis and properties of 3-(ethylthio)-9-methyl-6-(alkylthio)pyrazolo[1,5-d][1,2,4]triazolo[3,4-f][1,2,4]triazines
by: S. O. Fedotov, et al.
Published: (2022-12-01)

Synthesis, structure and properties of some 5-R-4-phenyl-1,2,4-triazole-3-thiol derivatives
by: A. S. Hotsulia
Published: (2019-12-01)

Synthesis, physical and chemical properties of 5-(adamantane-1-yl)-4-amino-1,2,4-triazole-3-thiol derivatives
by: V. M. Odyntsova
Published: (2016-12-01)

Synthesis and properties of some S-derivatives of 4-phenyl-5-((5-phenylamino-1,3,4-thiadiazole-2-ylthio)methyl)-1,2,4-triazole-3-thione
by: A. S. Hotsulia, et al.
Published: (2019-12-01)

Synthesis of some New 1,2,4-Triazole derivatives
by: Ibtehal Kahtan Abdullah
Published: (2013-11-01)

Physical-chemical properties of 5-(3-fluorophenyl)-4-amino-1,2,4-triazole-3-thiol s-derivatives
by: O. A. Bihdan, et al.
Published: (2017-08-01)

Synthesis and structure of new 4-amino-5-(2-R1-phenyl)-1,2,4-triazole-3-thiol alkilderivatives
by: Ye. S. Pruglo
Published: (2017-08-01)

Preparation of novel acyl pyrazoles and triazoles by means of oxidative functionalization reactions
by: Wadey Geoffrey P., et al.
Published: (2023-02-01)

Synthesis, antimicrobial and antioxidant activity of triazole, pyrazole containing thiazole derivatives and molecular docking studies on COVID-19
by: Raghavender Matta, et al.
Published: (2023-06-01)

Synthesis and properties of 5-(((5-amino-1,3,4-thiadiazole-2-yl)thio)methyl)-4-phenyl-1,2,4-triazole-3-thione and its some S-derivatives
by: A. S. Hotsulia, et al.
Published: (2020-08-01)

4-Cyclohexyl-3-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione
by: Joel T. Mague, et al.
Published: (2017-01-01)

4-(3-Methylphenyl)-3-[(3-methyl-5-phenyl-1H-pyrazol-1-yl)methyl]-4,5-dihydro-1H-1,2,4-triazole-5-thione
by: Joel T. Mague, et al.
Published: (2017-02-01)

Pyrazole and Triazole Derivatives as <i>Mycobacterium tuberculosis</i> UDP-Galactopyranose Inhibitors
by: Dalia M. Ahmed, et al.
Published: (2022-02-01)

Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives
by: R. El-Sayed
Published: (2006-06-01)

Synthesis, molecular docking, and ADME analysis of a series of 4-amino-3,5-dimethyl-1,2,4-triazole derivatives
by: L. I. Kucherenko, et al.
Published: (2023-07-01)

Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity
by: Anna V. Konkova, et al.
Published: (2023-12-01)

Synthesis of Novel Pyrazole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity
by: Zengfei Cai, et al.
Published: (2022-09-01)

Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives
by: Hong Dai, et al.
Published: (2017-11-01)

Microwave-assisted synthesis of new pyrazole derivatives bearing 1,2,3-triazole scaffold as potential antimicrobial agents
by: Ashok Dongamanti, et al.
Published: (2017-01-01)

Synthesis of ylidene derivatives of 4-amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazole-3-thiol
by: I. I. Aksionova, et al.
Published: (2015-08-01)

Synthesis and properties of 7-((6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)methyl)theophyllines
by: K. D. Bakumovska, et al.
Published: (2023-02-01)

Synthesis and properties of 2-(4-phenyl-5-(((5-phenylamino-1,3,4-thiadiazole-2-yl)thio)methyl)-1,2,4-triazole-3-yl)thio)ethanoic acid and its salts
by: A. S. Hotsulia, et al.
Published: (2020-11-01)

Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamide and Isoxazolol Pyrazole Carboxylate
by: Jialong Sun, et al.
Published: (2015-03-01)

Synthesis, structure and properties of 7-((4-amino-5-thio-1,2,4-triazole-3-yl)methyl)-theophylline derivatives
by: A. S. Hotsulia, et al.
Published: (2020-08-01)

Synthesis, antitumor activity, antimicrobial evaluation and molecular docking studies of some hydrazone, 1,3,4-oxadiazole, 1,2,4-triazole and pyrazole derivatives bearing nicotinoyl moiety
by: Abdel-Rahman Farghaly, et al.
Published: (2024-01-01)

Mono-Alkylated Ligands Based on Pyrazole and Triazole Derivatives Tested Against Fusarium oxysporum f. sp. albedinis: Synthesis, Characterization, DFT, and Phytase Binding Site Identification Using Blind Docking/Virtual Screening for Potent Fophy Inhibitors
by: Yassine Kaddouri, et al.
Published: (2020-12-01)

3-[5-Methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-1-phenyl-1H-pyrazole-4-carbaldehyde
by: Gamal A. El-Hiti, et al.
Published: (2019-02-01)

In silico evaluation of the pharmacodynamic component of the interaction of S-alkyl derivatives of 5-methyl-4-(p-tolyl)-1,2,4-triazole-3-thiol with some biological targets
by: O. I. Panasenko, et al.
Published: (2023-11-01)

In silico study of new bis-3R, 4R′-5-(((1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thione derivatives
by: Ye. O. Karpun, et al.
Published: (2019-12-01)

Synthesis and physical-chemical properties of some 5-(3-fluorophenyl)-4-methyl-1,2,4-triazole-3-thiol derivatives
by: O. A. Bihdan, et al.
Published: (2018-08-01)

Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing a 5-Trifluoromethylpyridyl Moiety
by: Hong Dai, et al.
Published: (2016-02-01)

Synthesis and physical-chemical properties of 3-alkylthio-5-(quinoline-2-yl, 2-hydroxyquinoline-4-yl)-4-R-2,4-dihydro-3H-1,2,4-triazoles
by: T. M. Kaplaushenko, et al.
Published: (2016-06-01)

Design, Synthesis, and In Vitro and In Vivo Antifungal Activity of Novel Triazoles Containing Phenylethynyl Pyrazole Side Chains
by: Tingjunhong Ni, et al.
Published: (2022-05-01)

Synthesis, physical and chemical properties of 2-((4-R-3-(morfolinomethylen)-4H-1,2,4-triazole-5-yl)thio)acetic acid salts
by: R. О. Shcherbyna
Published: (2017-04-01)