Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni
Schistosomiasis endangers the lives of greater than 200 million people every year and is predominantly controlled by a single class chemotherapy, praziquantel (PZQ). Development of PZQ replacement (to combat the threat of PZQ insensitivity/resistance arising) or combinatorial (to facilitate the kill...
Main Authors: | Gilda Padalino, Salvatore Ferla, Andrea Brancale, Iain W. Chalmers, Karl F. Hoffmann |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-12-01
|
Series: | International Journal for Parasitology: Drugs and Drug Resistance |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211320718301337 |
Similar Items
-
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes [version 1; peer review: 2 approved]
by: Iain W. Chalmers, et al.
Published: (2023-03-01) -
Analysis of regulatory protease sequences identified through bioinformatic data mining of the <it>Schistosoma mansoni </it>genome
by: Minchella Dennis J, et al.
Published: (2009-10-01) -
Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae.
by: Thomas A Gasan, et al.
Published: (2021-11-01) -
Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7.
by: Natalie Reimers, et al.
Published: (2015-03-01) -
Pathogenesis of Schistosoma mansoni infection
by: Allen W. Cheever
Published: (1992-01-01)