Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration
Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cel...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/11/2189 |
| _version_ | 1797469297014996992 |
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| author | Ryo Terao Tazbir Ahmed Ayana Suzumura Hiroko Terasaki |
| author_facet | Ryo Terao Tazbir Ahmed Ayana Suzumura Hiroko Terasaki |
| author_sort | Ryo Terao |
| collection | DOAJ |
| description | Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cellular response characterized by cell cycle arrest. Cellular senescence is an important contributor to aging and age-related diseases through the alteration of cellular function and the secretion of senescence-associated secretory phenotypes. As a driver of stress-induced premature senescence, oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers via reactive oxygen species and mitochondrial dysfunction. In this review, we focused on the mechanism of oxidative stress-induced senescence in retinal cells and its role in the pathogenesis of AMD. |
| first_indexed | 2024-03-09T19:19:23Z |
| format | Article |
| id | doaj.art-c2d4b6648fb642f2961126b0bce659b3 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T19:19:23Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c2d4b6648fb642f2961126b0bce659b32023-11-24T03:30:42ZengMDPI AGAntioxidants2076-39212022-11-011111218910.3390/antiox11112189Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular DegenerationRyo Terao0Tazbir Ahmed1Ayana Suzumura2Hiroko Terasaki3Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, JapanDepartment of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8654, JapanDepartment of Ophthalmology, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, JapanInstitutes of Innovation for Future Society, Nagoya University, Nagoya 464-8601, JapanAging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cellular response characterized by cell cycle arrest. Cellular senescence is an important contributor to aging and age-related diseases through the alteration of cellular function and the secretion of senescence-associated secretory phenotypes. As a driver of stress-induced premature senescence, oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers via reactive oxygen species and mitochondrial dysfunction. In this review, we focused on the mechanism of oxidative stress-induced senescence in retinal cells and its role in the pathogenesis of AMD.https://www.mdpi.com/2076-3921/11/11/2189agingage-related macular degenerationcellular senescenceinflammationoxidative stress |
| spellingShingle | Ryo Terao Tazbir Ahmed Ayana Suzumura Hiroko Terasaki Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration Antioxidants aging age-related macular degeneration cellular senescence inflammation oxidative stress |
| title | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
| title_full | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
| title_fullStr | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
| title_full_unstemmed | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
| title_short | Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration |
| title_sort | oxidative stress induced cellular senescence in aging retina and age related macular degeneration |
| topic | aging age-related macular degeneration cellular senescence inflammation oxidative stress |
| url | https://www.mdpi.com/2076-3921/11/11/2189 |
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