<i>PTEN</i> Alterations and Their Role in Cancer Management: Are We Making Headway on Precision Medicine?
Alterations in the tumor suppressor phosphatase and tensin homolog (<i>PTEN</i>) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian targ...
Main Authors: | Nicola Fusco, Elham Sajjadi, Konstantinos Venetis, Gabriella Gaudioso, Gianluca Lopez, Chiara Corti, Elena Guerini Rocco, Carmen Criscitiello, Umberto Malapelle, Marco Invernizzi |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
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Series: | Genes |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4425/11/7/719 |
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