Circulating neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy

Circulating neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy

Aims: To analyze the correlation between the neutrophil-to-lymphocyte ratio (NLR) and prognosis of advanced gastric cancer (AGC) patients treated by PD-1 antibody-based therapy and to delineate molecular characteristics of circulating neutrophils by single-cell RNA sequencing (scRNA-seq).Methods: Th...

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Bibliographic Details
Main Authors: Chenfei Zhou, Liting Guo, Qu Cai, Wenqi Xi, Fei Yuan, Huan Zhang, Chao Yan, Lei Huang, Zhenggang Zhu, Jun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
gastric cancer
neutrophils
immune checkpoint inhibitors
tumor microenvironment
PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1081762/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1081762/full

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