Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes

Molecular regulatory mechanisms of osteoclastogenesis through cytoprotective enzymes

It has been reported that reactive oxygen species (ROS), such as hydrogen peroxide and superoxide, take part in osteoclast differentiation as intra-cellular signaling molecules. The current assumed signaling cascade from RANK to ROS production is RANK, TRAF6, Rac1, and then Nox. The target molecules...

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Bibliographic Details
Main Authors: Hiroyuki Kanzaki, Fumiaki Shinohara, Itohiya Kanako, Yuuki Yamaguchi, Sari Fukaya, Yutaka Miyamoto, Satoshi Wada, Yoshiki Nakamura
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Redox Biology
Subjects:
Osteoclast
Oxidative stress
Heme-oxygenase 1 (HO-1)
Nrf2
FOXO
Sirtuin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716300052

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