Dietary Fat Intake and <i>KRAS</i> Mutations in Colorectal Cancer in a Moroccan Population
Epidemiologic data support an association between diet and mutations in the Kirsten-ras (<i>KRAS</i>) gene involved in colorectal cancer (CRC) development. This study aimed to explore the associations between fat intake and <i>KRAS</i> mutations in codons 12 and 13 in cases o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/2/318 |
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| author | Achraf El Asri Karim Ouldim Laila Bouguenouch Mohammed Sekal Fatima Zahra Moufid Ellen Kampman Inge Huybrechts Marc J. Gunter Sanae Abbaoui Kaoutar Znati Mehdi Karkouri Khaoula El Kinany Zineb Hatime Meimouna Mint Sidi Deoula Laila Chbani Btissame Zarrouq Karima El Rhazi |
| author_facet | Achraf El Asri Karim Ouldim Laila Bouguenouch Mohammed Sekal Fatima Zahra Moufid Ellen Kampman Inge Huybrechts Marc J. Gunter Sanae Abbaoui Kaoutar Znati Mehdi Karkouri Khaoula El Kinany Zineb Hatime Meimouna Mint Sidi Deoula Laila Chbani Btissame Zarrouq Karima El Rhazi |
| author_sort | Achraf El Asri |
| collection | DOAJ |
| description | Epidemiologic data support an association between diet and mutations in the Kirsten-ras (<i>KRAS</i>) gene involved in colorectal cancer (CRC) development. This study aimed to explore the associations between fat intake and <i>KRAS</i> mutations in codons 12 and 13 in cases of CRC in the Moroccan population. A multicenter case-series study nested in a large-scale Moroccan CRC case-control study was conducted. Among all CRC cases recruited, 151 specimens were available for the DNA mutation analysis. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (Cis) for <i>KRAS</i> mutation status according to the fat intake variables. A <i>KRAS</i> mutation was detected in the CRC tumor of 34.4% of the patients among whom 65.4% had a single mutation at codon 12 and 34.6% had a single mutation at codon 13. Compared to low levels of consumption, a positive association was observed between high polyunsaturated fatty acids (PUFA) consumption (>16.9 g/day) and prevalence of <i>KRAS</i> mutations (OR = 2.15, 95% CI = 1.01–4.59). No statistically significant associations were observed for total fat, monounsaturated fatty acids, saturated fatty acids and <i>KRAS</i> mutations. The results of this study suggest that PUFA may be relevant in the etiology of CRC, possibly through the generation of G > A transitions at the <i>KRAS</i> oncogene. Further studies are needed to verify and explain this finding. |
| first_indexed | 2024-03-10T00:47:24Z |
| format | Article |
| id | doaj.art-c2d5c48b02484fd8868f16fa98710635 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T00:47:24Z |
| publishDate | 2022-01-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c2d5c48b02484fd8868f16fa987106352023-11-23T14:57:30ZengMDPI AGNutrients2072-66432022-01-0114231810.3390/nu14020318Dietary Fat Intake and <i>KRAS</i> Mutations in Colorectal Cancer in a Moroccan PopulationAchraf El Asri0Karim Ouldim1Laila Bouguenouch2Mohammed Sekal3Fatima Zahra Moufid4Ellen Kampman5Inge Huybrechts6Marc J. Gunter7Sanae Abbaoui8Kaoutar Znati9Mehdi Karkouri10Khaoula El Kinany11Zineb Hatime12Meimouna Mint Sidi Deoula13Laila Chbani14Btissame Zarrouq15Karima El Rhazi16Laboratory of Epidemiology and Research in Health Sciences, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoMedical Genetics and Oncogenetics Unit, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoMedical Genetics and Oncogenetics Unit, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoDepartment of Anatomy and Cytopathology, Hassan II University Hospital, Sidi Mohammed Ben Abdallah University, Fez 30000, MoroccoMedical Genetics and Oncogenetics Unit, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoDivision of Human Nutrition and Health, Wageningen University and Research, 69000 Wageningen, The NetherlandsNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 69372 Lyon, FranceNutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, 69372 Lyon, FranceFaculty of Medicine and Pharmacy, Ibn Zohr University, Agadir 80035, MoroccoDepartment of Pathology, Ibn Sina University Hospital, Mohammed V University, Rabat 10001, MoroccoPathologic Anatomy and Cytology Laboratory, Ibn Rochd University Hospital, Casablanca 20360, MoroccoLaboratory of Epidemiology and Research in Health Sciences, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoLaboratory of Epidemiology and Research in Health Sciences, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoLaboratory of Epidemiology and Research in Health Sciences, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoDepartment of Anatomy and Cytopathology, Hassan II University Hospital, Sidi Mohammed Ben Abdallah University, Fez 30000, MoroccoLaboratory of Epidemiology and Research in Health Sciences, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoLaboratory of Epidemiology and Research in Health Sciences, Department of Epidemiology and Public Health, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez 30000, MoroccoEpidemiologic data support an association between diet and mutations in the Kirsten-ras (<i>KRAS</i>) gene involved in colorectal cancer (CRC) development. This study aimed to explore the associations between fat intake and <i>KRAS</i> mutations in codons 12 and 13 in cases of CRC in the Moroccan population. A multicenter case-series study nested in a large-scale Moroccan CRC case-control study was conducted. Among all CRC cases recruited, 151 specimens were available for the DNA mutation analysis. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (Cis) for <i>KRAS</i> mutation status according to the fat intake variables. A <i>KRAS</i> mutation was detected in the CRC tumor of 34.4% of the patients among whom 65.4% had a single mutation at codon 12 and 34.6% had a single mutation at codon 13. Compared to low levels of consumption, a positive association was observed between high polyunsaturated fatty acids (PUFA) consumption (>16.9 g/day) and prevalence of <i>KRAS</i> mutations (OR = 2.15, 95% CI = 1.01–4.59). No statistically significant associations were observed for total fat, monounsaturated fatty acids, saturated fatty acids and <i>KRAS</i> mutations. The results of this study suggest that PUFA may be relevant in the etiology of CRC, possibly through the generation of G > A transitions at the <i>KRAS</i> oncogene. Further studies are needed to verify and explain this finding.https://www.mdpi.com/2072-6643/14/2/318colorectal cancer<i>KRAS</i> mutationsdietfat intakeMoroccan population |
| spellingShingle | Achraf El Asri Karim Ouldim Laila Bouguenouch Mohammed Sekal Fatima Zahra Moufid Ellen Kampman Inge Huybrechts Marc J. Gunter Sanae Abbaoui Kaoutar Znati Mehdi Karkouri Khaoula El Kinany Zineb Hatime Meimouna Mint Sidi Deoula Laila Chbani Btissame Zarrouq Karima El Rhazi Dietary Fat Intake and <i>KRAS</i> Mutations in Colorectal Cancer in a Moroccan Population Nutrients colorectal cancer <i>KRAS</i> mutations diet fat intake Moroccan population |
| title | Dietary Fat Intake and <i>KRAS</i> Mutations in Colorectal Cancer in a Moroccan Population |
| title_full | Dietary Fat Intake and <i>KRAS</i> Mutations in Colorectal Cancer in a Moroccan Population |
| title_fullStr | Dietary Fat Intake and <i>KRAS</i> Mutations in Colorectal Cancer in a Moroccan Population |
| title_full_unstemmed | Dietary Fat Intake and <i>KRAS</i> Mutations in Colorectal Cancer in a Moroccan Population |
| title_short | Dietary Fat Intake and <i>KRAS</i> Mutations in Colorectal Cancer in a Moroccan Population |
| title_sort | dietary fat intake and i kras i mutations in colorectal cancer in a moroccan population |
| topic | colorectal cancer <i>KRAS</i> mutations diet fat intake Moroccan population |
| url | https://www.mdpi.com/2072-6643/14/2/318 |
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