Sleep and Late-Onset Alzheimer’s Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects

Sleep and Late-Onset Alzheimer’s Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects

Late-onset Alzheimer’s disease (AD) is associated with sleep-related phenotypes (SRPs). The fact that whether they share a common genetic etiology remains largely unknown. We explored the shared genetics and causality between AD and SRPs by using high-definition likelihood (HDL), cross-phenotype ass...

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Bibliographic Details
Main Authors: Dongze Chen, Xinpei Wang, Tao Huang, Jinzhu Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Genetics
Subjects:
sleep
late-onset Alzheimer’s disease
common genetic etiology
genetic correlation
Mendelian randomization
transcriptome-wide association study
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.794202/full

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