Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside
Investigating the neurocircuit and synaptic sites of action of oxytocin (OT) in the brain is critical to the role of OT in social memory and behavior. To the same degree, it is important to understand how OT is transported to the brain from the peripheral circulation. To date, of these, many studies...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.858070/full |
| _version_ | 1828333766885507072 |
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| author | Haruhiro Higashida Haruhiro Higashida Kazumi Furuhara Olga Lopatina Olga Lopatina Maria Gerasimenko Osamu Hori Tsuyoshi Hattori Yasuhiko Hayashi Stanislav M. Cherepanov Anna A. Shabalova Alla B. Salmina Alla B. Salmina Kana Minami Teruko Yuhi Chiharu Tsuji PinYue Fu Zhongyu Liu Shuxin Luo Anpei Zhang Shigeru Yokoyama Satoshi Shuto Mizuki Watanabe Koichi Fujiwara Sei-ichi Munesue Ai Harashima Yasuhiko Yamamoto |
| author_facet | Haruhiro Higashida Haruhiro Higashida Kazumi Furuhara Olga Lopatina Olga Lopatina Maria Gerasimenko Osamu Hori Tsuyoshi Hattori Yasuhiko Hayashi Stanislav M. Cherepanov Anna A. Shabalova Alla B. Salmina Alla B. Salmina Kana Minami Teruko Yuhi Chiharu Tsuji PinYue Fu Zhongyu Liu Shuxin Luo Anpei Zhang Shigeru Yokoyama Satoshi Shuto Mizuki Watanabe Koichi Fujiwara Sei-ichi Munesue Ai Harashima Yasuhiko Yamamoto |
| author_sort | Haruhiro Higashida |
| collection | DOAJ |
| description | Investigating the neurocircuit and synaptic sites of action of oxytocin (OT) in the brain is critical to the role of OT in social memory and behavior. To the same degree, it is important to understand how OT is transported to the brain from the peripheral circulation. To date, of these, many studies provide evidence that CD38, CD157, and receptor for advanced glycation end-products (RAGE) act as regulators of OT concentrations in the brain and blood. It has been shown that RAGE facilitates the uptake of OT in mother’s milk from the digestive tract to the cell surface of intestinal epithelial cells to the body fluid and subsequently into circulation in male mice. RAGE has been shown to recruit circulatory OT into the brain from blood at the endothelial cell surface of neurovascular units. Therefore, it can be said that extracellular OT concentrations in the brain (hypothalamus) could be determined by the transport of OT by RAGE from the circulation and release of OT from oxytocinergic neurons by CD38 and CD157 in mice. In addition, it has recently been found that gavage application of a precursor of nicotinamide adenine dinucleotide, nicotinamide riboside, for 12 days can increase brain OT in mice. Here, we review the evaluation of the new concept that RAGE is involved in the regulation of OT dynamics at the interface between the brain, blood, and intestine in the living body, mainly by summarizing our recent results due to the limited number of publications on related topics. And we also review other possible routes of OT recruitment to the brain. |
| first_indexed | 2024-04-13T21:24:29Z |
| format | Article |
| id | doaj.art-c2d8d57e74ea4a7ea7cc04abd8f5f32f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T21:24:29Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-c2d8d57e74ea4a7ea7cc04abd8f5f32f2022-12-22T02:29:22ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-07-011610.3389/fnins.2022.858070858070Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide RibosideHaruhiro Higashida0Haruhiro Higashida1Kazumi Furuhara2Olga Lopatina3Olga Lopatina4Maria Gerasimenko5Osamu Hori6Tsuyoshi Hattori7Yasuhiko Hayashi8Stanislav M. Cherepanov9Anna A. Shabalova10Alla B. Salmina11Alla B. Salmina12Kana Minami13Teruko Yuhi14Chiharu Tsuji15PinYue Fu16Zhongyu Liu17Shuxin Luo18Anpei Zhang19Shigeru Yokoyama20Satoshi Shuto21Mizuki Watanabe22Koichi Fujiwara23Sei-ichi Munesue24Ai Harashima25Yasuhiko Yamamoto26Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanLaboratory of Social Brain Study, Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Krasnoyarsk, RussiaDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanLaboratory of Social Brain Study, Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Krasnoyarsk, RussiaDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Neuroanatomy, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Neurosurgery, Kanazawa Medical University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanLaboratory of Social Brain Study, Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Krasnoyarsk, RussiaDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanDepartment of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa, JapanFaculty of Pharmaceutical Sciences, Center for Research and Education on Drug Discovery, Hokkaido University, Sapporo, JapanFaculty of Pharmaceutical Sciences, Center for Research and Education on Drug Discovery, Hokkaido University, Sapporo, JapanFaculty of Pharmaceutical Sciences, Center for Research and Education on Drug Discovery, Hokkaido University, Sapporo, JapanDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanInvestigating the neurocircuit and synaptic sites of action of oxytocin (OT) in the brain is critical to the role of OT in social memory and behavior. To the same degree, it is important to understand how OT is transported to the brain from the peripheral circulation. To date, of these, many studies provide evidence that CD38, CD157, and receptor for advanced glycation end-products (RAGE) act as regulators of OT concentrations in the brain and blood. It has been shown that RAGE facilitates the uptake of OT in mother’s milk from the digestive tract to the cell surface of intestinal epithelial cells to the body fluid and subsequently into circulation in male mice. RAGE has been shown to recruit circulatory OT into the brain from blood at the endothelial cell surface of neurovascular units. Therefore, it can be said that extracellular OT concentrations in the brain (hypothalamus) could be determined by the transport of OT by RAGE from the circulation and release of OT from oxytocinergic neurons by CD38 and CD157 in mice. In addition, it has recently been found that gavage application of a precursor of nicotinamide adenine dinucleotide, nicotinamide riboside, for 12 days can increase brain OT in mice. Here, we review the evaluation of the new concept that RAGE is involved in the regulation of OT dynamics at the interface between the brain, blood, and intestine in the living body, mainly by summarizing our recent results due to the limited number of publications on related topics. And we also review other possible routes of OT recruitment to the brain.https://www.frontiersin.org/articles/10.3389/fnins.2022.858070/fulloxytocinRAGEtransportendothelial cellsCD38 |
| spellingShingle | Haruhiro Higashida Haruhiro Higashida Kazumi Furuhara Olga Lopatina Olga Lopatina Maria Gerasimenko Osamu Hori Tsuyoshi Hattori Yasuhiko Hayashi Stanislav M. Cherepanov Anna A. Shabalova Alla B. Salmina Alla B. Salmina Kana Minami Teruko Yuhi Chiharu Tsuji PinYue Fu Zhongyu Liu Shuxin Luo Anpei Zhang Shigeru Yokoyama Satoshi Shuto Mizuki Watanabe Koichi Fujiwara Sei-ichi Munesue Ai Harashima Yasuhiko Yamamoto Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside Frontiers in Neuroscience oxytocin RAGE transport endothelial cells CD38 |
| title | Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside |
| title_full | Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside |
| title_fullStr | Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside |
| title_full_unstemmed | Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside |
| title_short | Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside |
| title_sort | oxytocin dynamics in the body and brain regulated by the receptor for advanced glycation end products cd38 cd157 and nicotinamide riboside |
| topic | oxytocin RAGE transport endothelial cells CD38 |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.858070/full |
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