PURE RED CELL APLASIA INDUCED BY ERYTHROPOIETIN
Introduction: Recombined human erythropoietin has been present in clinical practice for more than 20 years, in these therapeutic indications: anemia in kidney insufficiency, anemia during chemotherapy of tumors, prevention of anemias that appear in premature born babies, it is used for increasing au...
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| Format: | Article |
| Language: | English |
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Association of medical doctors Sanamed Novi Pazar
2018-05-01
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| Series: | Sanamed |
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| Online Access: | http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/197/106 |
| _version_ | 1827334668000690176 |
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| author | MIhajlovic Filip Milosavljevic Aleksandar Djuric Dusan |
| author_facet | MIhajlovic Filip Milosavljevic Aleksandar Djuric Dusan |
| author_sort | MIhajlovic Filip |
| collection | DOAJ |
| description | Introduction: Recombined human erythropoietin has been present in clinical practice for more than 20 years, in these therapeutic indications: anemia in kidney insufficiency, anemia during chemotherapy of tumors, prevention of anemias that appear in premature born babies, it is used for increasing autologous blood cell levels before blood transfusion, AIDS joined anemia (intensified by zidovudine), anemia joined with chronic inflammatory conditions such as rheumatoid arthritis(still in research phase). During the course of Erythropoietin treatment side effects have been noticed, that include multiple organ systems, and have different levels of frequency. Major number of studies shows connection between erythropoietin treatment and bone marrow aplasia, but small number of them states clearly defined side-effect that explains this phenomenon.
Objective: Goal of this paper is to analyze available case studies of bone marrow aplasia during erythropoietin application, access their quality and causality of every study.
Method: Research of literature used for the preparation of this systematic review has been conducted during the period of November- December 2017. In search for literature medical base PubMed has been used. Inclusion criteria were: available full article, publications in English language, publications conducted on humans, and case report studies. Eight studies passed selection.
Results: results were presented by 5 charts: documentation size, credibility, number of case study reports of side-effects in the paper that was graded, Naranjo causality score, data extraction chart. Mean grade value of the studies quality was 7,0, while mean Naranjo score was 6,6. |
| first_indexed | 2024-03-07T18:00:02Z |
| format | Article |
| id | doaj.art-c2daee3bcdd74a87a4bb79e79b305477 |
| institution | Directory Open Access Journal |
| issn | 1452-662X 2217-8171 |
| language | English |
| last_indexed | 2024-03-07T18:00:02Z |
| publishDate | 2018-05-01 |
| publisher | Association of medical doctors Sanamed Novi Pazar |
| record_format | Article |
| series | Sanamed |
| spelling | doaj.art-c2daee3bcdd74a87a4bb79e79b3054772024-03-02T11:06:18ZengAssociation of medical doctors Sanamed Novi PazarSanamed1452-662X2217-81712018-05-01131616810.24125/sanamed.v13i1.197PURE RED CELL APLASIA INDUCED BY ERYTHROPOIETINMIhajlovic Filip0Milosavljevic Aleksandar1Djuric Dusan2 Faculty of medical sciences, University of Kragujevac, SerbiaFaculty of medical sciences, University of Kragujevac, SerbiaFaculty of medical sciences, University of Kragujevac, SerbiaIntroduction: Recombined human erythropoietin has been present in clinical practice for more than 20 years, in these therapeutic indications: anemia in kidney insufficiency, anemia during chemotherapy of tumors, prevention of anemias that appear in premature born babies, it is used for increasing autologous blood cell levels before blood transfusion, AIDS joined anemia (intensified by zidovudine), anemia joined with chronic inflammatory conditions such as rheumatoid arthritis(still in research phase). During the course of Erythropoietin treatment side effects have been noticed, that include multiple organ systems, and have different levels of frequency. Major number of studies shows connection between erythropoietin treatment and bone marrow aplasia, but small number of them states clearly defined side-effect that explains this phenomenon. Objective: Goal of this paper is to analyze available case studies of bone marrow aplasia during erythropoietin application, access their quality and causality of every study. Method: Research of literature used for the preparation of this systematic review has been conducted during the period of November- December 2017. In search for literature medical base PubMed has been used. Inclusion criteria were: available full article, publications in English language, publications conducted on humans, and case report studies. Eight studies passed selection. Results: results were presented by 5 charts: documentation size, credibility, number of case study reports of side-effects in the paper that was graded, Naranjo causality score, data extraction chart. Mean grade value of the studies quality was 7,0, while mean Naranjo score was 6,6.http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/197/106erythropoietin side effectsanti-erythropoietin antibodiespure red cell aplasia. |
| spellingShingle | MIhajlovic Filip Milosavljevic Aleksandar Djuric Dusan PURE RED CELL APLASIA INDUCED BY ERYTHROPOIETIN Sanamed erythropoietin side effects anti-erythropoietin antibodies pure red cell aplasia. |
| title | PURE RED CELL APLASIA INDUCED BY ERYTHROPOIETIN |
| title_full | PURE RED CELL APLASIA INDUCED BY ERYTHROPOIETIN |
| title_fullStr | PURE RED CELL APLASIA INDUCED BY ERYTHROPOIETIN |
| title_full_unstemmed | PURE RED CELL APLASIA INDUCED BY ERYTHROPOIETIN |
| title_short | PURE RED CELL APLASIA INDUCED BY ERYTHROPOIETIN |
| title_sort | pure red cell aplasia induced by erythropoietin |
| topic | erythropoietin side effects anti-erythropoietin antibodies pure red cell aplasia. |
| url | http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/197/106 |
| work_keys_str_mv | AT mihajlovicfilip pureredcellaplasiainducedbyerythropoietin AT milosavljevicaleksandar pureredcellaplasiainducedbyerythropoietin AT djuricdusan pureredcellaplasiainducedbyerythropoietin |