Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population
To compare the cancer detection rate in patients with raised serum prostate-specific antigen (PSA) or abnormal digital rectal examination (DRE) results between the 10-core and the 16-core biopsy techniques in an Indian population. Methods: Between November 2010 and November 2012, 95 men aged >50...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
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Elsevier
2013-12-01
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| Colección: | Prostate International |
| Materias: | |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S2287888215300362 |
| _version_ | 1827842348499861504 |
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| author | V. Surya Prakash G. Chandra Mohan S. Venkata Krishnaiah V. Vijaykumar G. Ramesh Babu G. Vijaya Bhaskar Reddy |
| author_facet | V. Surya Prakash G. Chandra Mohan S. Venkata Krishnaiah V. Vijaykumar G. Ramesh Babu G. Vijaya Bhaskar Reddy |
| author_sort | V. Surya Prakash |
| collection | DOAJ |
| description | To compare the cancer detection rate in patients with raised serum prostate-specific antigen (PSA) or abnormal digital rectal examination (DRE) results between the 10-core and the 16-core biopsy techniques in an Indian population.
Methods: Between November 2010 and November 2012, 95 men aged >50 years who presented to the Urology Department with lower urinary tract symptoms, elevated serum PSA, and/or abnormal DRE findings underwent transrectal ultrasonography (TRUS)-guided prostate biopsy. A total of 53 patients underwent 10-core biopsy and 42 patients underwent 16-core biopsy.
Results: Of the 53 men in the 10-core group, 8 had cancer, whereas in the 16-core biopsy group, 23 of 42 men had cancer. Detection of prostate cancer was significantly higher in patients who underwent 16-core biopsy than in those who underwent 10-core biopsy (P<0.001). Among the 95 men, 44 men had abnormal DRE findings (46.3%), of whom 23 showed cancer (52.27%). Of 51 men with normal DRE findings and elevated PSA, 8 men had malignancy with a cancer detection rate of 15.68%. Among 20 men with PSA between 4.1 and 10 ng/mL, 2 (10%) had cancer. In 31 men with PSA between 10.1 and 20 ng/mL, 3 cancers (9.67%) were detected, and in 44 men with PSA >20 ng/mL, 26 cancers were detected (59.09%).
Conclusions: The cancer detection rate with 16-core TRUS-guided biopsy is significantly higher than that with 10-core biopsy (54.76% vs. 15.09%, P<0.001). In patients with both normal and abnormal DRE findings, 16-core biopsy has a better detection rate than the 10-core biopsy protocol. With increasing PSA, there is a high rate of detection of prostate cancer in both 10-core and 16-core biopsy patients. |
| first_indexed | 2024-03-12T08:08:11Z |
| format | Article |
| id | doaj.art-c2dc311de60f41f1bcbf901bddef4414 |
| institution | Directory Open Access Journal |
| issn | 2287-8882 |
| language | English |
| last_indexed | 2024-03-12T08:08:11Z |
| publishDate | 2013-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Prostate International |
| spelling | doaj.art-c2dc311de60f41f1bcbf901bddef44142023-09-02T19:21:14ZengElsevierProstate International2287-88822013-12-011416316810.12954/PI.13025Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian populationV. Surya PrakashG. Chandra MohanS. Venkata KrishnaiahV. VijaykumarG. Ramesh BabuG. Vijaya Bhaskar ReddyTo compare the cancer detection rate in patients with raised serum prostate-specific antigen (PSA) or abnormal digital rectal examination (DRE) results between the 10-core and the 16-core biopsy techniques in an Indian population. Methods: Between November 2010 and November 2012, 95 men aged >50 years who presented to the Urology Department with lower urinary tract symptoms, elevated serum PSA, and/or abnormal DRE findings underwent transrectal ultrasonography (TRUS)-guided prostate biopsy. A total of 53 patients underwent 10-core biopsy and 42 patients underwent 16-core biopsy. Results: Of the 53 men in the 10-core group, 8 had cancer, whereas in the 16-core biopsy group, 23 of 42 men had cancer. Detection of prostate cancer was significantly higher in patients who underwent 16-core biopsy than in those who underwent 10-core biopsy (P<0.001). Among the 95 men, 44 men had abnormal DRE findings (46.3%), of whom 23 showed cancer (52.27%). Of 51 men with normal DRE findings and elevated PSA, 8 men had malignancy with a cancer detection rate of 15.68%. Among 20 men with PSA between 4.1 and 10 ng/mL, 2 (10%) had cancer. In 31 men with PSA between 10.1 and 20 ng/mL, 3 cancers (9.67%) were detected, and in 44 men with PSA >20 ng/mL, 26 cancers were detected (59.09%). Conclusions: The cancer detection rate with 16-core TRUS-guided biopsy is significantly higher than that with 10-core biopsy (54.76% vs. 15.09%, P<0.001). In patients with both normal and abnormal DRE findings, 16-core biopsy has a better detection rate than the 10-core biopsy protocol. With increasing PSA, there is a high rate of detection of prostate cancer in both 10-core and 16-core biopsy patients.http://www.sciencedirect.com/science/article/pii/S2287888215300362Prostate neoplasmsProstate-specific antigenDigital rectal examinationTransrectal ultrasonographyProstate biopsy |
| spellingShingle | V. Surya Prakash G. Chandra Mohan S. Venkata Krishnaiah V. Vijaykumar G. Ramesh Babu G. Vijaya Bhaskar Reddy Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population Prostate International Prostate neoplasms Prostate-specific antigen Digital rectal examination Transrectal ultrasonography Prostate biopsy |
| title | Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population |
| title_full | Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population |
| title_fullStr | Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population |
| title_full_unstemmed | Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population |
| title_short | Ten-core versus 16-core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma: a prospective comparative study in Indian population |
| title_sort | ten core versus 16 core transrectal ultrasonography guided prostate biopsy for detection of prostatic carcinoma a prospective comparative study in indian population |
| topic | Prostate neoplasms Prostate-specific antigen Digital rectal examination Transrectal ultrasonography Prostate biopsy |
| url | http://www.sciencedirect.com/science/article/pii/S2287888215300362 |
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