Axon guidance gene-targeted siRNA delivery system improves neural stem cell transplantation therapy after spinal cord injury

Axon guidance gene-targeted siRNA delivery system improves neural stem cell transplantation therapy after spinal cord injury

Abstract Background Neural stem cells (NSCs) derived from the embryonic spinal cord are excellent candidates for the cellular regeneration of lost neural cells after spinal cord injury (SCI). Semaphorin 3 A (Sema3A) is well known as being implicated in the major axon guidance of the growth cone as a...

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Bibliographic Details
Main Authors: Seong Jun Kim, Wan-Kyu Ko, Gong Ho Han, Daye Lee, Min Jai Cho, Seung Hun Sheen, Seil Sohn
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023-10-01
Series:Biomaterials Research
Subjects:
Spinal cord injuries
Neural stem cells
Semaphorin-3A
Small interfering RNA
Axon guidance
Online Access:https://doi.org/10.1186/s40824-023-00434-2

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