Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensor
To address the urgent need for glucose level detection in the human body, several affordable, lightweight, and skin-mounted glucose sensors have been developed. Enzymatic sensors are frequently utilized, but they have challenges of enzyme degradation and indirect charge transfer through a redox medi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523007244 |
| _version_ | 1797647982012661760 |
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| author | Devesh K. Pathak Hong Chul Moon |
| author_facet | Devesh K. Pathak Hong Chul Moon |
| author_sort | Devesh K. Pathak |
| collection | DOAJ |
| description | To address the urgent need for glucose level detection in the human body, several affordable, lightweight, and skin-mounted glucose sensors have been developed. Enzymatic sensors are frequently utilized, but they have challenges of enzyme degradation and indirect charge transfer through a redox mediator, which affect their reusability and shelf life. Here, enzyme-free nickel oxide thin film electrode in an alkaline medium is used to enable direct charge transfer with glucose. A chemical reaction between glucose and the electrode surface occurs, leading to an additional oxidation (Ni+2/Ni+3) of the electrode under external bias. Additionally, the colorimetric analysis further validated this reaction through the transformation of a dark-colored NiO (Ni+3) electrode into a bleached color state (reduced from Ni+3 to Ni+2) through the oxidation of glucose. As the glucose concentrations increase to 5 mM, the color of the electrode is no longer optically readable (ΔT% ∼ 66%). The corresponding amperometric response is determined with a detection limit of 2 μM and a 3579 μA mM−1 cm−2 sensitivity, and it also recognizes a passive response to other interfering species and facilitates its one-month shelf life. Additionally, a two-electrode electrochemical colorimetric liquid cell-type glucose sensor has been designed to pave the way for future applications. |
| first_indexed | 2024-03-11T15:24:34Z |
| format | Article |
| id | doaj.art-c2e010acaad64118b0351a75e9a232e4 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T15:24:34Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-c2e010acaad64118b0351a75e9a232e42023-10-28T05:06:24ZengElsevierMaterials & Design0264-12752023-10-01234112309Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensorDevesh K. Pathak0Hong Chul Moon1Department of Chemical Engineering, University of Seoul, Seoul 02504, Republic of KoreaCorresponding author.; Department of Chemical Engineering, University of Seoul, Seoul 02504, Republic of KoreaTo address the urgent need for glucose level detection in the human body, several affordable, lightweight, and skin-mounted glucose sensors have been developed. Enzymatic sensors are frequently utilized, but they have challenges of enzyme degradation and indirect charge transfer through a redox mediator, which affect their reusability and shelf life. Here, enzyme-free nickel oxide thin film electrode in an alkaline medium is used to enable direct charge transfer with glucose. A chemical reaction between glucose and the electrode surface occurs, leading to an additional oxidation (Ni+2/Ni+3) of the electrode under external bias. Additionally, the colorimetric analysis further validated this reaction through the transformation of a dark-colored NiO (Ni+3) electrode into a bleached color state (reduced from Ni+3 to Ni+2) through the oxidation of glucose. As the glucose concentrations increase to 5 mM, the color of the electrode is no longer optically readable (ΔT% ∼ 66%). The corresponding amperometric response is determined with a detection limit of 2 μM and a 3579 μA mM−1 cm−2 sensitivity, and it also recognizes a passive response to other interfering species and facilitates its one-month shelf life. Additionally, a two-electrode electrochemical colorimetric liquid cell-type glucose sensor has been designed to pave the way for future applications.http://www.sciencedirect.com/science/article/pii/S0264127523007244Glucose sensingEnzyme-freeChemical reactionElectrochromismReusable platform |
| spellingShingle | Devesh K. Pathak Hong Chul Moon Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensor Materials & Design Glucose sensing Enzyme-free Chemical reaction Electrochromism Reusable platform |
| title | Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensor |
| title_full | Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensor |
| title_fullStr | Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensor |
| title_full_unstemmed | Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensor |
| title_short | Enzyme-free, metal oxide-based amperometric-colorimetric dual-mode functional glucose sensor |
| title_sort | enzyme free metal oxide based amperometric colorimetric dual mode functional glucose sensor |
| topic | Glucose sensing Enzyme-free Chemical reaction Electrochromism Reusable platform |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523007244 |
| work_keys_str_mv | AT deveshkpathak enzymefreemetaloxidebasedamperometriccolorimetricdualmodefunctionalglucosesensor AT hongchulmoon enzymefreemetaloxidebasedamperometriccolorimetricdualmodefunctionalglucosesensor |