Progress in cancer neuroscience
Abstract Cancer of the central nervous system (CNS) can crosstalk systemically and locally in the tumor microenvironment and has become a topic of attention for tumor initiation and advancement. Recently studied neuronal and cancer interaction fundamentally altered the knowledge about glioma and met...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
|
| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.431 |
| _version_ | 1797373567016370176 |
|---|---|
| author | Yu‐Long Lan Shuang Zou Wen Wang Qi Chen Yongjian Zhu |
| author_facet | Yu‐Long Lan Shuang Zou Wen Wang Qi Chen Yongjian Zhu |
| author_sort | Yu‐Long Lan |
| collection | DOAJ |
| description | Abstract Cancer of the central nervous system (CNS) can crosstalk systemically and locally in the tumor microenvironment and has become a topic of attention for tumor initiation and advancement. Recently studied neuronal and cancer interaction fundamentally altered the knowledge about glioma and metastases, indicating how cancers invade complex neuronal networks. This review systematically discussed the interactions between neurons and cancers and elucidates new therapeutic avenues. We have overviewed the current understanding of direct or indirect communications of neuronal cells with cancer and the mechanisms associated with cancer invasion. Besides, tumor‐associated neuronal dysfunction and the influence of cancer therapies on the CNS are highlighted. Furthermore, interactions between peripheral nervous system and various cancers have also been discussed separately. Intriguingly and importantly, it cannot be ignored that exosomes could mediate the “wireless communications” between nervous system and cancer. Finally, promising future strategies targeting neuronal–brain tumor interactions were reviewed. A great deal of work remains to be done to elucidate the neuroscience of cancer, and future more research should be directed toward clarifying the precise mechanisms of cancer neuroscience, which hold enormous promise to improve outcomes for a wide range of malignancies. |
| first_indexed | 2024-03-08T18:52:21Z |
| format | Article |
| id | doaj.art-c2e109d27dbd4ec7b9ecb73a5949945d |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-03-08T18:52:21Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-c2e109d27dbd4ec7b9ecb73a5949945d2023-12-28T16:52:34ZengWileyMedComm2688-26632023-12-0146n/an/a10.1002/mco2.431Progress in cancer neuroscienceYu‐Long Lan0Shuang Zou1Wen Wang2Qi Chen3Yongjian Zhu4Department of Neurosurgery Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang ChinaKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Science Zhejiang Chinese Medical University Hangzhou ChinaDepartment of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing ChinaKey Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Science Zhejiang Chinese Medical University Hangzhou ChinaDepartment of Neurosurgery Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang ChinaAbstract Cancer of the central nervous system (CNS) can crosstalk systemically and locally in the tumor microenvironment and has become a topic of attention for tumor initiation and advancement. Recently studied neuronal and cancer interaction fundamentally altered the knowledge about glioma and metastases, indicating how cancers invade complex neuronal networks. This review systematically discussed the interactions between neurons and cancers and elucidates new therapeutic avenues. We have overviewed the current understanding of direct or indirect communications of neuronal cells with cancer and the mechanisms associated with cancer invasion. Besides, tumor‐associated neuronal dysfunction and the influence of cancer therapies on the CNS are highlighted. Furthermore, interactions between peripheral nervous system and various cancers have also been discussed separately. Intriguingly and importantly, it cannot be ignored that exosomes could mediate the “wireless communications” between nervous system and cancer. Finally, promising future strategies targeting neuronal–brain tumor interactions were reviewed. A great deal of work remains to be done to elucidate the neuroscience of cancer, and future more research should be directed toward clarifying the precise mechanisms of cancer neuroscience, which hold enormous promise to improve outcomes for a wide range of malignancies.https://doi.org/10.1002/mco2.431cancercancer neuroscienceinteractionneuronneurosciencetreatment |
| spellingShingle | Yu‐Long Lan Shuang Zou Wen Wang Qi Chen Yongjian Zhu Progress in cancer neuroscience MedComm cancer cancer neuroscience interaction neuron neuroscience treatment |
| title | Progress in cancer neuroscience |
| title_full | Progress in cancer neuroscience |
| title_fullStr | Progress in cancer neuroscience |
| title_full_unstemmed | Progress in cancer neuroscience |
| title_short | Progress in cancer neuroscience |
| title_sort | progress in cancer neuroscience |
| topic | cancer cancer neuroscience interaction neuron neuroscience treatment |
| url | https://doi.org/10.1002/mco2.431 |
| work_keys_str_mv | AT yulonglan progressincancerneuroscience AT shuangzou progressincancerneuroscience AT wenwang progressincancerneuroscience AT qichen progressincancerneuroscience AT yongjianzhu progressincancerneuroscience |