Mapping movement, mood, motivation and mentation in the subthalamic nucleus
The anatomical connections of the subthalamic nucleus (STN) have driven hypotheses about its functional anatomy, including the hypothesis that the precise anatomical location of STN deep brain stimulation (DBS) contributes to the variability of motor and non-motor responses across patients with Park...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2018-01-01
|
| Series: | Royal Society Open Science |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171177 |
| _version_ | 1819198921511010304 |
|---|---|
| author | Amritha Gourisankar Sarah A. Eisenstein Nicholas T. Trapp Jonathan M. Koller Meghan C. Campbell Mwiza Ushe Joel S. Perlmutter Tamara Hershey Kevin J. Black |
| author_facet | Amritha Gourisankar Sarah A. Eisenstein Nicholas T. Trapp Jonathan M. Koller Meghan C. Campbell Mwiza Ushe Joel S. Perlmutter Tamara Hershey Kevin J. Black |
| author_sort | Amritha Gourisankar |
| collection | DOAJ |
| description | The anatomical connections of the subthalamic nucleus (STN) have driven hypotheses about its functional anatomy, including the hypothesis that the precise anatomical location of STN deep brain stimulation (DBS) contributes to the variability of motor and non-motor responses across patients with Parkinson's disease (PD). We previously tested the hypothesis using a three-dimensional (3D) statistical method to interpret the acute effects of unilateral DBS at each patient's clinically optimized DBS settings and active contact. Here, we report a similar analysis from a new study in which DBS parameters were standardized and DBS locations were chosen blind to clinical response. In 74 individuals with PD and STN DBS, STN contacts were selected near the dorsal and ventral borders of the STN contralateral to the more affected side of the body. Participants were tested off PD medications in each of three unilateral DBS conditions (ventral STN DBS, dorsal STN DBS and DBS off) for acute effects on mood, apathy, working memory, response inhibition and motor function. Voltage, frequency and pulse width were standardized, and participants and raters were blind to condition. In a categorical analysis, both dorsal and ventral STN DBS improved mean motor function without affecting cognitive measures. Ventral STN DBS induced greater improvement in rigidity and anxiety than dorsal STN DBS. In the 3D analysis, contact location was significant for body hypokinesia, rigidity and resting tremor, with the greatest improvement occurring with DBS in dorsal STN and zona incerta. The 3D results provide new, direct functional evidence for the anatomically derived model of STN, in which motor function is best represented in dorsal STN. However, our data suggest that functional segregation between motor and non-motor areas of the STN is limited, because locations that induced improvements in motor function and mood overlapped substantially. |
| first_indexed | 2024-12-23T03:08:07Z |
| format | Article |
| id | doaj.art-c2e15f66a36b4a9f850fffcbbd0f67d2 |
| institution | Directory Open Access Journal |
| issn | 2054-5703 |
| language | English |
| last_indexed | 2024-12-23T03:08:07Z |
| publishDate | 2018-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj.art-c2e15f66a36b4a9f850fffcbbd0f67d22022-12-21T18:02:17ZengThe Royal SocietyRoyal Society Open Science2054-57032018-01-015710.1098/rsos.171177171177Mapping movement, mood, motivation and mentation in the subthalamic nucleusAmritha GourisankarSarah A. EisensteinNicholas T. TrappJonathan M. KollerMeghan C. CampbellMwiza UsheJoel S. PerlmutterTamara HersheyKevin J. BlackThe anatomical connections of the subthalamic nucleus (STN) have driven hypotheses about its functional anatomy, including the hypothesis that the precise anatomical location of STN deep brain stimulation (DBS) contributes to the variability of motor and non-motor responses across patients with Parkinson's disease (PD). We previously tested the hypothesis using a three-dimensional (3D) statistical method to interpret the acute effects of unilateral DBS at each patient's clinically optimized DBS settings and active contact. Here, we report a similar analysis from a new study in which DBS parameters were standardized and DBS locations were chosen blind to clinical response. In 74 individuals with PD and STN DBS, STN contacts were selected near the dorsal and ventral borders of the STN contralateral to the more affected side of the body. Participants were tested off PD medications in each of three unilateral DBS conditions (ventral STN DBS, dorsal STN DBS and DBS off) for acute effects on mood, apathy, working memory, response inhibition and motor function. Voltage, frequency and pulse width were standardized, and participants and raters were blind to condition. In a categorical analysis, both dorsal and ventral STN DBS improved mean motor function without affecting cognitive measures. Ventral STN DBS induced greater improvement in rigidity and anxiety than dorsal STN DBS. In the 3D analysis, contact location was significant for body hypokinesia, rigidity and resting tremor, with the greatest improvement occurring with DBS in dorsal STN and zona incerta. The 3D results provide new, direct functional evidence for the anatomically derived model of STN, in which motor function is best represented in dorsal STN. However, our data suggest that functional segregation between motor and non-motor areas of the STN is limited, because locations that induced improvements in motor function and mood overlapped substantially.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171177subthalamic nucleusdeep brain stimulationparkinson's diseaseemotionsinhibition (psychology)short-term memory |
| spellingShingle | Amritha Gourisankar Sarah A. Eisenstein Nicholas T. Trapp Jonathan M. Koller Meghan C. Campbell Mwiza Ushe Joel S. Perlmutter Tamara Hershey Kevin J. Black Mapping movement, mood, motivation and mentation in the subthalamic nucleus Royal Society Open Science subthalamic nucleus deep brain stimulation parkinson's disease emotions inhibition (psychology) short-term memory |
| title | Mapping movement, mood, motivation and mentation in the subthalamic nucleus |
| title_full | Mapping movement, mood, motivation and mentation in the subthalamic nucleus |
| title_fullStr | Mapping movement, mood, motivation and mentation in the subthalamic nucleus |
| title_full_unstemmed | Mapping movement, mood, motivation and mentation in the subthalamic nucleus |
| title_short | Mapping movement, mood, motivation and mentation in the subthalamic nucleus |
| title_sort | mapping movement mood motivation and mentation in the subthalamic nucleus |
| topic | subthalamic nucleus deep brain stimulation parkinson's disease emotions inhibition (psychology) short-term memory |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.171177 |
| work_keys_str_mv | AT amrithagourisankar mappingmovementmoodmotivationandmentationinthesubthalamicnucleus AT sarahaeisenstein mappingmovementmoodmotivationandmentationinthesubthalamicnucleus AT nicholasttrapp mappingmovementmoodmotivationandmentationinthesubthalamicnucleus AT jonathanmkoller mappingmovementmoodmotivationandmentationinthesubthalamicnucleus AT meghanccampbell mappingmovementmoodmotivationandmentationinthesubthalamicnucleus AT mwizaushe mappingmovementmoodmotivationandmentationinthesubthalamicnucleus AT joelsperlmutter mappingmovementmoodmotivationandmentationinthesubthalamicnucleus AT tamarahershey mappingmovementmoodmotivationandmentationinthesubthalamicnucleus AT kevinjblack mappingmovementmoodmotivationandmentationinthesubthalamicnucleus |