Safety and Efficacy of Drug-Eluting Beads Trans-Arterial Chemoembolization for Hepatocellular Carcinoma in Taiwan (SERENADE-T)
Yi-Sheng Liu,1 Pi-Yi Chang,2 Po-Chin Liang,3 Ming-Ching Ou,4 Jen-I Hwang,5,6 Chien-Hung Chen7,8 1Department of Medical Imaging, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Radiology, Taichung Veterans General Hospital,...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-08-01
|
| Series: | Journal of Hepatocellular Carcinoma |
| Subjects: | |
| Online Access: | https://www.dovepress.com/safety-and-efficacy-of-drug-eluting-beads-trans-arterial-chemoemboliza-peer-reviewed-fulltext-article-JHC |
| _version_ | 1811283847064584192 |
|---|---|
| author | Liu YS Chang PY Liang PC Ou MC Hwang JI Chen CH |
| author_facet | Liu YS Chang PY Liang PC Ou MC Hwang JI Chen CH |
| author_sort | Liu YS |
| collection | DOAJ |
| description | Yi-Sheng Liu,1 Pi-Yi Chang,2 Po-Chin Liang,3 Ming-Ching Ou,4 Jen-I Hwang,5,6 Chien-Hung Chen7,8 1Department of Medical Imaging, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Radiology, Taichung Veterans General Hospital, Taichung City, Taiwan; 3Department of Radiology, National Taiwan University Hospital, Taipei City, Taiwan; 4Department of Diagnostic Radiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 5Department of Medical Imaging, Tungs’ Taichung MetroHarbor Hospital, Taichung City, Taiwan; 6Department of Radiology, School of Medicine, National Defense Medical Center, Taipei City, Taiwan; 7Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan; 8Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, TaiwanCorrespondence: Chien-Hung Chen, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, No. 579, Sec. 2, Yunlin Road, Douliu City, Yunlin County, 640, Taiwan, Tel +886-2-23123456 ext. 65923, Fax +886-2-23819723, Email chenhcc@ntu.edu.twPurpose: The aim of this retrospective study was to evaluate the safety and efficacy of patients with hepatocellular carcinoma treated with drug-eluting bead with doxorubicin transarterial chemoembolization (DEBDOX-TACE) in Taiwan.Patients and Methods: We retrospectively investigated 630 hepatocellular carcinoma patients who underwent DEBDOX-TACE in multiple institutions from 2011 to 2016 in Taiwan. Tumor response was assessed per modified response evaluation criteria in solid tumors, overall survival, and safety.Results: This study included 630 patients who underwent DEBDOX-TACE, participants’ mean age was 66 years, 68.1% males and 15.6% females. The mean doxorubicin dose administered via DEBDOX-TACE was 56 mg. Complete and partial response rates were 14.6% and 49.2%, respectively, with a disease control rate of 84.6%. The median overall survival was 29.2 months. The most common post-embolization symptom was abdominal pain (22.4%). No hepatic encephalopathy and no procedure-related death were found.Conclusion: Real-world data from Taiwan demonstrated that DEBDOX-TACE for hepatocellular carcinoma can achieve high tumor response rate with low adverse events.Keywords: chemoembolization, DEBDOX, doxorubicin, liver cancer |
| first_indexed | 2024-04-13T02:18:29Z |
| format | Article |
| id | doaj.art-c2e1fc3bc2204afe82e732e13c5fbc22 |
| institution | Directory Open Access Journal |
| issn | 2253-5969 |
| language | English |
| last_indexed | 2024-04-13T02:18:29Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj.art-c2e1fc3bc2204afe82e732e13c5fbc222022-12-22T03:07:04ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692022-08-01Volume 981182177406Safety and Efficacy of Drug-Eluting Beads Trans-Arterial Chemoembolization for Hepatocellular Carcinoma in Taiwan (SERENADE-T)Liu YSChang PYLiang PCOu MCHwang JIChen CHYi-Sheng Liu,1 Pi-Yi Chang,2 Po-Chin Liang,3 Ming-Ching Ou,4 Jen-I Hwang,5,6 Chien-Hung Chen7,8 1Department of Medical Imaging, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Radiology, Taichung Veterans General Hospital, Taichung City, Taiwan; 3Department of Radiology, National Taiwan University Hospital, Taipei City, Taiwan; 4Department of Diagnostic Radiology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 5Department of Medical Imaging, Tungs’ Taichung MetroHarbor Hospital, Taichung City, Taiwan; 6Department of Radiology, School of Medicine, National Defense Medical Center, Taipei City, Taiwan; 7Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliu City, Yunlin County, Taiwan; 8Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, TaiwanCorrespondence: Chien-Hung Chen, Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, No. 579, Sec. 2, Yunlin Road, Douliu City, Yunlin County, 640, Taiwan, Tel +886-2-23123456 ext. 65923, Fax +886-2-23819723, Email chenhcc@ntu.edu.twPurpose: The aim of this retrospective study was to evaluate the safety and efficacy of patients with hepatocellular carcinoma treated with drug-eluting bead with doxorubicin transarterial chemoembolization (DEBDOX-TACE) in Taiwan.Patients and Methods: We retrospectively investigated 630 hepatocellular carcinoma patients who underwent DEBDOX-TACE in multiple institutions from 2011 to 2016 in Taiwan. Tumor response was assessed per modified response evaluation criteria in solid tumors, overall survival, and safety.Results: This study included 630 patients who underwent DEBDOX-TACE, participants’ mean age was 66 years, 68.1% males and 15.6% females. The mean doxorubicin dose administered via DEBDOX-TACE was 56 mg. Complete and partial response rates were 14.6% and 49.2%, respectively, with a disease control rate of 84.6%. The median overall survival was 29.2 months. The most common post-embolization symptom was abdominal pain (22.4%). No hepatic encephalopathy and no procedure-related death were found.Conclusion: Real-world data from Taiwan demonstrated that DEBDOX-TACE for hepatocellular carcinoma can achieve high tumor response rate with low adverse events.Keywords: chemoembolization, DEBDOX, doxorubicin, liver cancerhttps://www.dovepress.com/safety-and-efficacy-of-drug-eluting-beads-trans-arterial-chemoemboliza-peer-reviewed-fulltext-article-JHCchemoembolizationdebdoxdoxorubicinliver cancer |
| spellingShingle | Liu YS Chang PY Liang PC Ou MC Hwang JI Chen CH Safety and Efficacy of Drug-Eluting Beads Trans-Arterial Chemoembolization for Hepatocellular Carcinoma in Taiwan (SERENADE-T) Journal of Hepatocellular Carcinoma chemoembolization debdox doxorubicin liver cancer |
| title | Safety and Efficacy of Drug-Eluting Beads Trans-Arterial Chemoembolization for Hepatocellular Carcinoma in Taiwan (SERENADE-T) |
| title_full | Safety and Efficacy of Drug-Eluting Beads Trans-Arterial Chemoembolization for Hepatocellular Carcinoma in Taiwan (SERENADE-T) |
| title_fullStr | Safety and Efficacy of Drug-Eluting Beads Trans-Arterial Chemoembolization for Hepatocellular Carcinoma in Taiwan (SERENADE-T) |
| title_full_unstemmed | Safety and Efficacy of Drug-Eluting Beads Trans-Arterial Chemoembolization for Hepatocellular Carcinoma in Taiwan (SERENADE-T) |
| title_short | Safety and Efficacy of Drug-Eluting Beads Trans-Arterial Chemoembolization for Hepatocellular Carcinoma in Taiwan (SERENADE-T) |
| title_sort | safety and efficacy of drug eluting beads trans arterial chemoembolization for hepatocellular carcinoma in taiwan serenade t |
| topic | chemoembolization debdox doxorubicin liver cancer |
| url | https://www.dovepress.com/safety-and-efficacy-of-drug-eluting-beads-trans-arterial-chemoemboliza-peer-reviewed-fulltext-article-JHC |
| work_keys_str_mv | AT liuys safetyandefficacyofdrugelutingbeadstransarterialchemoembolizationforhepatocellularcarcinomaintaiwanserenadet AT changpy safetyandefficacyofdrugelutingbeadstransarterialchemoembolizationforhepatocellularcarcinomaintaiwanserenadet AT liangpc safetyandefficacyofdrugelutingbeadstransarterialchemoembolizationforhepatocellularcarcinomaintaiwanserenadet AT oumc safetyandefficacyofdrugelutingbeadstransarterialchemoembolizationforhepatocellularcarcinomaintaiwanserenadet AT hwangji safetyandefficacyofdrugelutingbeadstransarterialchemoembolizationforhepatocellularcarcinomaintaiwanserenadet AT chench safetyandefficacyofdrugelutingbeadstransarterialchemoembolizationforhepatocellularcarcinomaintaiwanserenadet |