Single‐cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers

Single‐cell and spatial analyses reveal the association between gene expression of glutamine synthetase with the immunosuppressive phenotype of APOE+CTSZ+TAM in cancers

An immunosuppressive state is regulated by various factors in the tumor microenvironment (TME), including, but not limited to, metabolic plasticity of immunosuppressive cells and cytokines secreted by these cells. We used single‐cell RNA‐sequencing (scRNA‐seq) data and applied single‐cell flux estim...

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Bibliographic Details
Main Authors: Jinfen Wei, Wenqi Yu, Juanzhi Chen, Guanda Huang, Lingjie Zhang, Zixi Chen, Meiling Hu, Xiaocheng Gong, Hongli Du
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Molecular Oncology
Subjects:
colorectal cancer
GLUL
immunosuppressive microenvironment
metabolism
single‐cell and spatial RNA‐seq
tumor‐associated macrophages
Online Access:https://doi.org/10.1002/1878-0261.13373

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