Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment
White matter hyperintensity of presumed vascular origin (WMH) is a common medical imaging manifestation in the brains of middle-aged and elderly individuals. WMH can lead to cognitive decline and an increased risk of cognitive impairment and dementia. However, the pathogenesis of cognitive impairmen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.865920/full |
| _version_ | 1811323300131897344 |
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| author | Fanhua Meng Ying Yang Guangwei Jin |
| author_facet | Fanhua Meng Ying Yang Guangwei Jin |
| author_sort | Fanhua Meng |
| collection | DOAJ |
| description | White matter hyperintensity of presumed vascular origin (WMH) is a common medical imaging manifestation in the brains of middle-aged and elderly individuals. WMH can lead to cognitive decline and an increased risk of cognitive impairment and dementia. However, the pathogenesis of cognitive impairment in patients with WMH remains unclear. WMH increases the risk of cognitive impairment, the nature and severity of which depend on lesion volume and location and the patient's cognitive reserve. Abnormal changes in microstructure, cerebral blood flow, metabolites, and resting brain function are observed in patients with WMH with cognitive impairment. Magnetic resonance imaging (MRI) is an indispensable tool for detecting WMH, and novel MRI techniques have emerged as the key approaches for exploring WMH and cognitive impairment. This article provides an overview of the association between WMH and cognitive impairment and the application of dynamic contrast-enhanced MRI, structural MRI, diffusion tensor imaging, 3D-arterial spin labeling, intravoxel incoherent motion, magnetic resonance spectroscopy, and resting-state functional MRI for examining WMH and cognitive impairment. |
| first_indexed | 2024-04-13T13:52:27Z |
| format | Article |
| id | doaj.art-c2e6d43a148a48bba5a52ccf2d32d0e1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T13:52:27Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c2e6d43a148a48bba5a52ccf2d32d0e12022-12-22T02:44:18ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-07-011310.3389/fneur.2022.865920865920Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive ImpairmentFanhua Meng0Ying Yang1Guangwei Jin2North China University of Science and Technology, Tangshan, ChinaDepartment of Radiology, China Emergency General Hospital, Beijing, ChinaDepartment of Radiology, China Emergency General Hospital, Beijing, ChinaWhite matter hyperintensity of presumed vascular origin (WMH) is a common medical imaging manifestation in the brains of middle-aged and elderly individuals. WMH can lead to cognitive decline and an increased risk of cognitive impairment and dementia. However, the pathogenesis of cognitive impairment in patients with WMH remains unclear. WMH increases the risk of cognitive impairment, the nature and severity of which depend on lesion volume and location and the patient's cognitive reserve. Abnormal changes in microstructure, cerebral blood flow, metabolites, and resting brain function are observed in patients with WMH with cognitive impairment. Magnetic resonance imaging (MRI) is an indispensable tool for detecting WMH, and novel MRI techniques have emerged as the key approaches for exploring WMH and cognitive impairment. This article provides an overview of the association between WMH and cognitive impairment and the application of dynamic contrast-enhanced MRI, structural MRI, diffusion tensor imaging, 3D-arterial spin labeling, intravoxel incoherent motion, magnetic resonance spectroscopy, and resting-state functional MRI for examining WMH and cognitive impairment.https://www.frontiersin.org/articles/10.3389/fneur.2022.865920/fullwhite matter hyperintensities of presumed vascular origincerebral small vascular diseasecognitive impairmentmagnetic resonance imagingneuroimagingwhite matter |
| spellingShingle | Fanhua Meng Ying Yang Guangwei Jin Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment Frontiers in Neurology white matter hyperintensities of presumed vascular origin cerebral small vascular disease cognitive impairment magnetic resonance imaging neuroimaging white matter |
| title | Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment |
| title_full | Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment |
| title_fullStr | Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment |
| title_full_unstemmed | Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment |
| title_short | Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment |
| title_sort | research progress on mri for white matter hyperintensity of presumed vascular origin and cognitive impairment |
| topic | white matter hyperintensities of presumed vascular origin cerebral small vascular disease cognitive impairment magnetic resonance imaging neuroimaging white matter |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.865920/full |
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