Cadmium Exposure Enhances Bisphenol A-Induced Genotoxicity through 8-Oxoguanine-DNA Glycosylase-1 OGG1 Inhibition in NIH3T3 Fibroblast Cells

Cadmium Exposure Enhances Bisphenol A-Induced Genotoxicity through 8-Oxoguanine-DNA Glycosylase-1 OGG1 Inhibition in NIH3T3 Fibroblast Cells

Background: Both cadmium (Cd) and bisphenol A (BPA) are commonly encountered in humans' daily activities, but their combined genotoxic effects remain unclear. Methods: In the present study, we exposed a mouse embryonic fibroblast cell line (NIH3T3) to Cd for 24 h, followed by a 24 h BPA exposur...

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Bibliographic Details
Main Authors: Zhi-Yu Chen, Chuan Liu, Yong-hui Lu, Ling-Ling Yang, Min Li, Min-Di He, Chun-Hai Chen, Lei Zhang, Zheng-Ping Yu, Zhou Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cadmium
Bisphenol A
Genotoxicity
Cytotoxicity
OGG1
Online Access:http://www.karger.com/Article/FullText/447804

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