Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis
The etiology of intervertebral disc degeneration (IDD) and osteoarthritis (OA) is complex and multifactorial. Both predisposing genes and environmental factors are involved in the pathogenesis of IDD and OA. Moreover, epigenetic modifications affect the development of IDD and OA. Dysregulated phenot...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
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Wiley
2023-12-01
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Series: | Orthopaedic Surgery |
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Online Access: | https://doi.org/10.1111/os.13851 |
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author | Wen Li Xing‐Hua Li Yang Gao Cheng‐Jie Xiong Zhong‐Zhi Tang |
author_facet | Wen Li Xing‐Hua Li Yang Gao Cheng‐Jie Xiong Zhong‐Zhi Tang |
author_sort | Wen Li |
collection | DOAJ |
description | The etiology of intervertebral disc degeneration (IDD) and osteoarthritis (OA) is complex and multifactorial. Both predisposing genes and environmental factors are involved in the pathogenesis of IDD and OA. Moreover, epigenetic modifications affect the development of IDD and OA. Dysregulated phenotypes of nucleus pulposus (NP) cells and OA chondrocytes, including apoptosis, extracellular matrix disruption, inflammation, and angiogenesis, are involved at all developmental stages of IDD and OA. RNA binding proteins (RBPs) have recently been recognized as essential post‐transcriptional regulators of gene expression. RBPs are implicated in many cellular processes, such as proliferation, differentiation, and apoptosis. Recently, several RBPs have been reported to be associated with the pathogenesis of IDD and OA. This review briefly summarizes the current knowledge on the RNA‐regulatory networks controlled by RBPs and their potential roles in the pathogenesis of IDD and OA. These initial findings support the idea that specific modulation of RBPs represents a promising approach for managing IDD and OA. |
first_indexed | 2024-03-09T03:12:14Z |
format | Article |
id | doaj.art-c2eb0a1dcf5c45788c8da2051dc14626 |
institution | Directory Open Access Journal |
issn | 1757-7853 1757-7861 |
language | English |
last_indexed | 2024-03-09T03:12:14Z |
publishDate | 2023-12-01 |
publisher | Wiley |
record_format | Article |
series | Orthopaedic Surgery |
spelling | doaj.art-c2eb0a1dcf5c45788c8da2051dc146262023-12-04T02:35:48ZengWileyOrthopaedic Surgery1757-78531757-78612023-12-0115123015302510.1111/os.13851Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritisWen Li0Xing‐Hua Li1Yang Gao2Cheng‐Jie Xiong3Zhong‐Zhi Tang4Department of Emergency General Hospital of Central Theater Command of PLA Wuhan ChinaDepartment of Emergency General Hospital of Central Theater Command of PLA Wuhan ChinaDepartment of Orthopaedic General Hospital of Central Theater Command of PLA Wuhan ChinaDepartment of Orthopaedic General Hospital of Central Theater Command of PLA Wuhan ChinaDepartment of Emergency General Hospital of Central Theater Command of PLA Wuhan ChinaThe etiology of intervertebral disc degeneration (IDD) and osteoarthritis (OA) is complex and multifactorial. Both predisposing genes and environmental factors are involved in the pathogenesis of IDD and OA. Moreover, epigenetic modifications affect the development of IDD and OA. Dysregulated phenotypes of nucleus pulposus (NP) cells and OA chondrocytes, including apoptosis, extracellular matrix disruption, inflammation, and angiogenesis, are involved at all developmental stages of IDD and OA. RNA binding proteins (RBPs) have recently been recognized as essential post‐transcriptional regulators of gene expression. RBPs are implicated in many cellular processes, such as proliferation, differentiation, and apoptosis. Recently, several RBPs have been reported to be associated with the pathogenesis of IDD and OA. This review briefly summarizes the current knowledge on the RNA‐regulatory networks controlled by RBPs and their potential roles in the pathogenesis of IDD and OA. These initial findings support the idea that specific modulation of RBPs represents a promising approach for managing IDD and OA.https://doi.org/10.1111/os.13851Intervertebral Disc DegenerationOsteoarthritisPost‐Transcriptional Gene RegulationRNA Binding Proteins |
spellingShingle | Wen Li Xing‐Hua Li Yang Gao Cheng‐Jie Xiong Zhong‐Zhi Tang Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis Orthopaedic Surgery Intervertebral Disc Degeneration Osteoarthritis Post‐Transcriptional Gene Regulation RNA Binding Proteins |
title | Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis |
title_full | Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis |
title_fullStr | Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis |
title_full_unstemmed | Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis |
title_short | Emerging roles of RNA binding proteins in intervertebral disc degeneration and osteoarthritis |
title_sort | emerging roles of rna binding proteins in intervertebral disc degeneration and osteoarthritis |
topic | Intervertebral Disc Degeneration Osteoarthritis Post‐Transcriptional Gene Regulation RNA Binding Proteins |
url | https://doi.org/10.1111/os.13851 |
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