The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature
<p>Abstract</p> <p>Background</p> <p>ABCG2, also known as BCRP, is a half ATP-binding cassette (ABC) transporter that localizes to plasma membranes. Recently, a number of studies have investigated the relationship between the C421A polymorphism in ABCG2 and cancer risk...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
|
| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/12/383 |
| _version_ | 1818485656632950784 |
|---|---|
| author | Chen Pin Zhao Lin Zou Peng Xu Haitao Lu Ailin Zhao Peng |
| author_facet | Chen Pin Zhao Lin Zou Peng Xu Haitao Lu Ailin Zhao Peng |
| author_sort | Chen Pin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>ABCG2, also known as BCRP, is a half ATP-binding cassette (ABC) transporter that localizes to plasma membranes. Recently, a number of studies have investigated the relationship between the C421A polymorphism in ABCG2 and cancer risk in multiple populations and various types of cancers; however, this relationship remains unclear. Therefore, we performed a meta-analysis to further explore this association.</p> <p>Methods</p> <p>The meta-analysis incorporated 10 studies involving a total of 3593 cases and 5875 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated based on the date extracted from the studies to evaluate the strength of association. We also analyzed the heterogeneity and sensitivity of each report and the publication bias of the studies.</p> <p>Results</p> <p>Overall, our results showed that there appeared to be a significant association between the ABCG2 C421A polymorphism and decreased cancer susceptibility (heterozygote-AC versus CC: OR = 0.759, 95%CI = 0.620-0.930; dominant effects model-AA/AC versus CC: OR = 0.771, 95%CI = 0.634-0.938; additive effects model-A allele versus C allele: OR = 0.809, 95%CI = 0.687-0.952). Similarly, decreased cancer risk was also found after stratification of the SNP data by cancer type, ethnicity and source of controls in heterozygote model, dominant effects model and additive effects model.</p> <p>Conclusions</p> <p>We found that the ABCG2 C421A polymorphism is a protective factor for developing cancer. The same relationship was found when the studies were stratified by cancer type, ethnicity and source of controls.</p> |
| first_indexed | 2024-12-10T16:11:52Z |
| format | Article |
| id | doaj.art-c2eb135432c14a26b5d990a4aea84713 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-10T16:11:52Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-c2eb135432c14a26b5d990a4aea847132022-12-22T01:42:05ZengBMCBMC Cancer1471-24072012-09-0112138310.1186/1471-2407-12-383The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literatureChen PinZhao LinZou PengXu HaitaoLu AilinZhao Peng<p>Abstract</p> <p>Background</p> <p>ABCG2, also known as BCRP, is a half ATP-binding cassette (ABC) transporter that localizes to plasma membranes. Recently, a number of studies have investigated the relationship between the C421A polymorphism in ABCG2 and cancer risk in multiple populations and various types of cancers; however, this relationship remains unclear. Therefore, we performed a meta-analysis to further explore this association.</p> <p>Methods</p> <p>The meta-analysis incorporated 10 studies involving a total of 3593 cases and 5875 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated based on the date extracted from the studies to evaluate the strength of association. We also analyzed the heterogeneity and sensitivity of each report and the publication bias of the studies.</p> <p>Results</p> <p>Overall, our results showed that there appeared to be a significant association between the ABCG2 C421A polymorphism and decreased cancer susceptibility (heterozygote-AC versus CC: OR = 0.759, 95%CI = 0.620-0.930; dominant effects model-AA/AC versus CC: OR = 0.771, 95%CI = 0.634-0.938; additive effects model-A allele versus C allele: OR = 0.809, 95%CI = 0.687-0.952). Similarly, decreased cancer risk was also found after stratification of the SNP data by cancer type, ethnicity and source of controls in heterozygote model, dominant effects model and additive effects model.</p> <p>Conclusions</p> <p>We found that the ABCG2 C421A polymorphism is a protective factor for developing cancer. The same relationship was found when the studies were stratified by cancer type, ethnicity and source of controls.</p>http://www.biomedcentral.com/1471-2407/12/383 |
| spellingShingle | Chen Pin Zhao Lin Zou Peng Xu Haitao Lu Ailin Zhao Peng The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature BMC Cancer |
| title | The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature |
| title_full | The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature |
| title_fullStr | The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature |
| title_full_unstemmed | The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature |
| title_short | The contribution of the ABCG2 C421A polymorphism to cancer susceptibility: a meta-analysis of the current literature |
| title_sort | contribution of the abcg2 c421a polymorphism to cancer susceptibility a meta analysis of the current literature |
| url | http://www.biomedcentral.com/1471-2407/12/383 |
| work_keys_str_mv | AT chenpin thecontributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT zhaolin thecontributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT zoupeng thecontributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT xuhaitao thecontributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT luailin thecontributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT zhaopeng thecontributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT chenpin contributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT zhaolin contributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT zoupeng contributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT xuhaitao contributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT luailin contributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature AT zhaopeng contributionoftheabcg2c421apolymorphismtocancersusceptibilityametaanalysisofthecurrentliterature |