The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

Effective mucosal adjuvants enhance the magnitude and quality of the vaccine response. Cyclic di-GMP (CDG) is a promising mucosal vaccine adjuvant. However, its in vivo mechanisms are unclear. Here, we showed, in mice, that CDG elicits stronger Ab and TH responses than the mammalian 2′3′-cyclic GMP-...

Full description

Bibliographic Details
Main Authors: Steven M Blaauboer, Samira Mansouri, Heidi R Tucker, Hatti L Wang, Vincent D Gabrielle, Lei Jin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-04-01
Series:eLife
Subjects:
mucosal adjuvant
STING
dendritic cell
pneumococcal vaccine
lung
Online Access:https://elifesciences.org/articles/06670

Internet

https://elifesciences.org/articles/06670

Similar Items