Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver
The polyamines spermidine, spermine and putrescine are essential for normal cellular functions. The contents of polyamines in tissue decreased in aged mice compared to young mice. In this study, the polyamine contents and their metabolic byproduct acrolein-conjugated lysine (Nε-(3-formyl-3,4-dehydro...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-09-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020318740 |
| _version_ | 1818307084210405376 |
|---|---|
| author | Takeshi Uemura Yoshihisa Akasaka Hiroshi Ikegaya |
| author_facet | Takeshi Uemura Yoshihisa Akasaka Hiroshi Ikegaya |
| author_sort | Takeshi Uemura |
| collection | DOAJ |
| description | The polyamines spermidine, spermine and putrescine are essential for normal cellular functions. The contents of polyamines in tissue decreased in aged mice compared to young mice. In this study, the polyamine contents and their metabolic byproduct acrolein-conjugated lysine (Nε-(3-formyl-3,4-dehydropiperidino)-lysine, FDP-Lys) in human liver tissue were measured and analyzed the correlation with age of the subjects. The putrescine and FDP-Lys levels were significantly increased with age. On the other hand, spermine level was decreased with age. Spermidine did not significantly correlate with age. The relative amount of spermine oxidase (SMOX) significantly correlated with the age of subjects whereas ornithine decarboxylase (ODC) and adenosylmethionine decarboxylase (AMD1) significantly reduced by the age. Our results suggested that an increase in oxidation and reduction in polyamine synthesis may cause the change of polyamine profile in the elderly. |
| first_indexed | 2024-12-13T06:52:45Z |
| format | Article |
| id | doaj.art-c2f011fb552d4637a5e8ce694ea88c1d |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-13T06:52:45Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c2f011fb552d4637a5e8ce694ea88c1d2022-12-21T23:56:06ZengElsevierHeliyon2405-84402020-09-0169e05031Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liverTakeshi Uemura0Yoshihisa Akasaka1Hiroshi Ikegaya2Amine Pharma Research Institute, 1-8-15 Inohana, Chuo-ku, Chiba 260-0856, Japan; Department of Forensic Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan; Corresponding author.Department of Forensic Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Forensic Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanThe polyamines spermidine, spermine and putrescine are essential for normal cellular functions. The contents of polyamines in tissue decreased in aged mice compared to young mice. In this study, the polyamine contents and their metabolic byproduct acrolein-conjugated lysine (Nε-(3-formyl-3,4-dehydropiperidino)-lysine, FDP-Lys) in human liver tissue were measured and analyzed the correlation with age of the subjects. The putrescine and FDP-Lys levels were significantly increased with age. On the other hand, spermine level was decreased with age. Spermidine did not significantly correlate with age. The relative amount of spermine oxidase (SMOX) significantly correlated with the age of subjects whereas ornithine decarboxylase (ODC) and adenosylmethionine decarboxylase (AMD1) significantly reduced by the age. Our results suggested that an increase in oxidation and reduction in polyamine synthesis may cause the change of polyamine profile in the elderly.http://www.sciencedirect.com/science/article/pii/S2405844020318740BiochemistryOxidative stressBiomoleculesAgingBiomarkersPolyamine |
| spellingShingle | Takeshi Uemura Yoshihisa Akasaka Hiroshi Ikegaya Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver Heliyon Biochemistry Oxidative stress Biomolecules Aging Biomarkers Polyamine |
| title | Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver |
| title_full | Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver |
| title_fullStr | Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver |
| title_full_unstemmed | Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver |
| title_short | Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver |
| title_sort | correlation of polyamines acrolein conjugated lysine and polyamine metabolic enzyme levels with age in human liver |
| topic | Biochemistry Oxidative stress Biomolecules Aging Biomarkers Polyamine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020318740 |
| work_keys_str_mv | AT takeshiuemura correlationofpolyaminesacroleinconjugatedlysineandpolyaminemetabolicenzymelevelswithageinhumanliver AT yoshihisaakasaka correlationofpolyaminesacroleinconjugatedlysineandpolyaminemetabolicenzymelevelswithageinhumanliver AT hiroshiikegaya correlationofpolyaminesacroleinconjugatedlysineandpolyaminemetabolicenzymelevelswithageinhumanliver |