Coordination Sites for Sodium and Potassium Ions in Nucleophilic Adeninate Contact ion-Pairs: A Molecular-Wide and Electron Density-Based (MOWED) Perspective

Coordination Sites for Sodium and Potassium Ions in Nucleophilic Adeninate Contact ion-Pairs: A Molecular-Wide and Electron Density-Based (MOWED) Perspective

The adeninate anion (Ade<sup>−</sup>) is a useful nucleophile used in the synthesis of many prodrugs (including those for HIV AIDS treatment). It exists as a contact ion-pair (CIP) with Na<sup>+</sup> and K<sup>+</sup> (M<sup>+</sup>) but the site of c...

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Bibliographic Details
Main Authors: Dominique M. S. Buyens, Lynne A. Pilcher, Ignacy Cukrowski
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
adeninate anion
nucleobases
alkali metals
ion-pairs
coordination modes
DMSO
Online Access:https://www.mdpi.com/1420-3049/27/18/6111

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