Relationship Between Plasma Homocystein Levels and Polyneuropaty in Patients Using Levodopa For Idiopathic Parkinson’s Disease
Objective: Recent studies showed high plasma homocysteine levels in patients treated with Levodopa for Parkinson’s disease (PD). Homocysteine, due to its exotoxic effect, might be the cause of polyneuropathy seen in PD. In this study, our aim was to show the correlation between high concentratio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2012-06-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: | http://www.hasekidergisi.com/article_4660/Relationship-Between-Plasma-Homocystein-Levels-And-Polyneuropaty-In-Patients-Using-Levodopa-For-Idiopathic-Parkinsons-Disease |
| Summary: | Objective: Recent studies showed high plasma homocysteine levels
in patients treated with Levodopa for Parkinson’s disease (PD).
Homocysteine, due to its exotoxic effect, might be the cause of
polyneuropathy seen in PD. In this study, our aim was to show the
correlation between high concentration of plasma homocysteine levels
and polyneuropathy associated with PD..
Material and Methods: Forty-one patients with PD receiving
levodopa treatment (patient group) and 30 healthy subjects (control
group) were included in this study. We compared the two groups in
terms of electrophysiological findings. Twelve patients had high
plasma homocysteine levels and 29 of them had low plasma
homocysteine levels.
Results: Six of the 41 patients had sensorial polyneuropathy and
decreased compound muscle action potantiel amplitude
compared to controls. Two patients had high plasma
homocysteine levels, two patients had nearly high plasma
homocysteine levels, two patients had low plasma homocysteine
levels who had sensorial polyneuropathy.
Conclusion: Although in our study, we did not show any
correlation between polyneuropathy and high plasma
homocysteine levels, further studies including homogeneous
groups of younger patients with PD are needed. (The Me di cal Bul -
le tin of Ha se ki 2012; 50: 53-8) |
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| ISSN: | 1302-0072 2147-2688 |