Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration?
The aims of this study were to analyze the relationship between the presence of the cilioretinal artery (CRA) and the incidence, severity and progression of age-related macular degeneration (AMD) and to estimate the influence of the CRA on choroidal and retinal parameters. A total of 287 patients wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/9/1593 |
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| author | Elżbieta Krytkowska Aleksandra Grabowicz Krzysztof Safranow Anna Machalińska |
| author_facet | Elżbieta Krytkowska Aleksandra Grabowicz Krzysztof Safranow Anna Machalińska |
| author_sort | Elżbieta Krytkowska |
| collection | DOAJ |
| description | The aims of this study were to analyze the relationship between the presence of the cilioretinal artery (CRA) and the incidence, severity and progression of age-related macular degeneration (AMD) and to estimate the influence of the CRA on choroidal and retinal parameters. A total of 287 patients with AMD and 110 healthy controls were enrolled in the study. CRA occurrence was determined using color fundus images. AMD progression was assessed after 3 years. There was no difference in the incidence of CRA between the AMD and control groups (23.34% vs. 24.55%; <i>p</i> = 0.8). Lower-stage AMD was more frequently observed in eyes with the CRA than in eyes without the artery (<i>p</i> = 0.016). The CRA did not influence disease progression (<i>p</i> = 0.79). The CRA did not influence retinal and choroidal thickness and volume parameters or the retinal vessel caliber and functionality in either the AMD or control groups. There was no relationship between CRA presence and CFH Y402H and ARMS2 A69S risk variants. The results did not show a protective effect of the CRA on the incidence and progression of AMD. The CRA may affect the severity of AMD; however, the mechanism of this phenomenon is unclear. |
| first_indexed | 2024-03-11T04:21:30Z |
| format | Article |
| id | doaj.art-c2f44cd7cc904a479ffba404d7b40cae |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T04:21:30Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-c2f44cd7cc904a479ffba404d7b40cae2023-11-17T22:45:48ZengMDPI AGDiagnostics2075-44182023-04-01139159310.3390/diagnostics13091593Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration?Elżbieta Krytkowska0Aleksandra Grabowicz1Krzysztof Safranow2Anna Machalińska3First Department of Ophthalmology, Pomeranian Medical University, 70-111 Szczecin, PolandFirst Department of Ophthalmology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, PolandFirst Department of Ophthalmology, Pomeranian Medical University, 70-111 Szczecin, PolandThe aims of this study were to analyze the relationship between the presence of the cilioretinal artery (CRA) and the incidence, severity and progression of age-related macular degeneration (AMD) and to estimate the influence of the CRA on choroidal and retinal parameters. A total of 287 patients with AMD and 110 healthy controls were enrolled in the study. CRA occurrence was determined using color fundus images. AMD progression was assessed after 3 years. There was no difference in the incidence of CRA between the AMD and control groups (23.34% vs. 24.55%; <i>p</i> = 0.8). Lower-stage AMD was more frequently observed in eyes with the CRA than in eyes without the artery (<i>p</i> = 0.016). The CRA did not influence disease progression (<i>p</i> = 0.79). The CRA did not influence retinal and choroidal thickness and volume parameters or the retinal vessel caliber and functionality in either the AMD or control groups. There was no relationship between CRA presence and CFH Y402H and ARMS2 A69S risk variants. The results did not show a protective effect of the CRA on the incidence and progression of AMD. The CRA may affect the severity of AMD; however, the mechanism of this phenomenon is unclear.https://www.mdpi.com/2075-4418/13/9/1593cilioretinal arteryage-related macular degeneration (AMD)choroidal thicknessCFH Y403HARMS2 A69S |
| spellingShingle | Elżbieta Krytkowska Aleksandra Grabowicz Krzysztof Safranow Anna Machalińska Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration? Diagnostics cilioretinal artery age-related macular degeneration (AMD) choroidal thickness CFH Y403H ARMS2 A69S |
| title | Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration? |
| title_full | Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration? |
| title_fullStr | Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration? |
| title_full_unstemmed | Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration? |
| title_short | Does the Presence of the Cilioretinal Artery Affect the Incidence, Clinical Picture and Progression of Age-Related Macular Degeneration? |
| title_sort | does the presence of the cilioretinal artery affect the incidence clinical picture and progression of age related macular degeneration |
| topic | cilioretinal artery age-related macular degeneration (AMD) choroidal thickness CFH Y403H ARMS2 A69S |
| url | https://www.mdpi.com/2075-4418/13/9/1593 |
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