Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet
Resveratrol (RES) is considered to be an activator of AMP-activated protein kinase (AMPK) with many reported health benefits. Polydatin (POD) is a natural precursor and glycosylated form of RES. The glycoside structure of POD alters the bioactivity. Overnutrition-stimulated reactive oxygen species (...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.857879/full |
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| author | Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Lian Yang Wenshen Zhong Yuze Hu Yu Tan Zhe Ren Zhe Ren Zhe Ren Qiuyan Ban Chung S. Yang Yifei Wang Yifei Wang Yifei Wang Zhiping Wang |
| author_facet | Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Lian Yang Wenshen Zhong Yuze Hu Yu Tan Zhe Ren Zhe Ren Zhe Ren Qiuyan Ban Chung S. Yang Yifei Wang Yifei Wang Yifei Wang Zhiping Wang |
| author_sort | Guangshan Zhao |
| collection | DOAJ |
| description | Resveratrol (RES) is considered to be an activator of AMP-activated protein kinase (AMPK) with many reported health benefits. Polydatin (POD) is a natural precursor and glycosylated form of RES. The glycoside structure of POD alters the bioactivity. Overnutrition-stimulated reactive oxygen species (ROS) promote the AMPK suppression and metabolic dysregulation. The present work compared the effects of POD and RES in ameliorating energy homeostasis imbalance in mice fed a high-fructose diet and elucidated the underlying mechanisms of action. Our results showed that POD elevated the fecal levels of valeric acid and caproic acid via modification of gut microbiota, while RES did not significantly influence the levels of fecal short-chain fatty acids (SCFAs). Both POD and RES markedly decreased the oxidative stress and activated the AMPK signaling pathways in the liver. POD and RES exerted a similar effect in alleviating glucose dysmetabolism, but POD was more effective in ameliorating lipid dysmetabolism than RES. Furthermore, valeric acid and caproic acid alone can activate the AMPK and ameliorate hypercholesterolemia, and enhance the effects of POD on improving lipid metabolism in mice. Overall, for the first time, we demonstrated that POD administration elevated the fecal levels of valeric acid and caproic acid by modifying gut microbiota, thus promoting AMPK activation may be the underlying mechanism that POD is superior to RES in alleviating the lipid dysmetabolism. Our results suggest that POD may be an alternative for RES as an AMPK activator. |
| first_indexed | 2024-12-12T04:17:26Z |
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| language | English |
| last_indexed | 2024-12-12T04:17:26Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-c2f5a9abdd6248d1aad07e294084dc562022-12-22T00:38:24ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.857879857879Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose DietGuangshan Zhao0Guangshan Zhao1Guangshan Zhao2Guangshan Zhao3Guangshan Zhao4Guangshan Zhao5Lian Yang6Wenshen Zhong7Yuze Hu8Yu Tan9Zhe Ren10Zhe Ren11Zhe Ren12Qiuyan Ban13Chung S. Yang14Yifei Wang15Yifei Wang16Yifei Wang17Zhiping Wang18Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaSchool of Food Science and Technology, Henan Agricultural University, Zhengzhou, ChinaGuangdong Province Key Laboratory of Bioengineering Medicine, Guangzhou, ChinaGuangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, ChinaGuangzhou Jinan Biomedicine Research and Development Center Co., Ltd., Guangzhou, ChinaGuangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaGuangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaGuangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, ChinaGuangzhou Jinan Biomedicine Research and Development Center Co., Ltd., Guangzhou, ChinaCollege of Horticulture, Henan Agricultural University, Zhengzhou, ChinaDepartment of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United StatesDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaGuangdong Provincial Biotechnology Drug and Engineering Technology Research Center, Guangzhou, ChinaGuangzhou Jinan Biomedicine Research and Development Center Co., Ltd., Guangzhou, ChinaGuangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaResveratrol (RES) is considered to be an activator of AMP-activated protein kinase (AMPK) with many reported health benefits. Polydatin (POD) is a natural precursor and glycosylated form of RES. The glycoside structure of POD alters the bioactivity. Overnutrition-stimulated reactive oxygen species (ROS) promote the AMPK suppression and metabolic dysregulation. The present work compared the effects of POD and RES in ameliorating energy homeostasis imbalance in mice fed a high-fructose diet and elucidated the underlying mechanisms of action. Our results showed that POD elevated the fecal levels of valeric acid and caproic acid via modification of gut microbiota, while RES did not significantly influence the levels of fecal short-chain fatty acids (SCFAs). Both POD and RES markedly decreased the oxidative stress and activated the AMPK signaling pathways in the liver. POD and RES exerted a similar effect in alleviating glucose dysmetabolism, but POD was more effective in ameliorating lipid dysmetabolism than RES. Furthermore, valeric acid and caproic acid alone can activate the AMPK and ameliorate hypercholesterolemia, and enhance the effects of POD on improving lipid metabolism in mice. Overall, for the first time, we demonstrated that POD administration elevated the fecal levels of valeric acid and caproic acid by modifying gut microbiota, thus promoting AMPK activation may be the underlying mechanism that POD is superior to RES in alleviating the lipid dysmetabolism. Our results suggest that POD may be an alternative for RES as an AMPK activator.https://www.frontiersin.org/articles/10.3389/fnut.2022.857879/fullpolydatinresveratrolnon-alcoholic fatty liver disease5′-aMP-activated protein kinasegut microbiotashort-chain fatty acids |
| spellingShingle | Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Guangshan Zhao Lian Yang Wenshen Zhong Yuze Hu Yu Tan Zhe Ren Zhe Ren Zhe Ren Qiuyan Ban Chung S. Yang Yifei Wang Yifei Wang Yifei Wang Zhiping Wang Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet Frontiers in Nutrition polydatin resveratrol non-alcoholic fatty liver disease 5′-aMP-activated protein kinase gut microbiota short-chain fatty acids |
| title | Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet |
| title_full | Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet |
| title_fullStr | Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet |
| title_full_unstemmed | Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet |
| title_short | Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet |
| title_sort | polydatin a glycoside of resveratrol is better than resveratrol in alleviating non alcoholic fatty liver disease in mice fed a high fructose diet |
| topic | polydatin resveratrol non-alcoholic fatty liver disease 5′-aMP-activated protein kinase gut microbiota short-chain fatty acids |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.857879/full |
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