Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice
The incidence of seizures increases with old age. Stroke, dementia and brain tumors are recognized risk factors for new-onset seizures in the aging populations and the incidence of these conditions also increased with age. Whether aging is associated with higher seizure susceptibility in the absence...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-12-01
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| Series: | IBRO Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451830117300249 |
| _version_ | 1811264843431280640 |
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| author | Kurt R. Stover Stellar Lim Terri-Lin Zhou Paul M. Stafford Jonathan Chow Haoyuan Li Nila Sivanenthiran Sivakami Mylvaganam Chiping Wu Donald F. Weaver James Eubanks Liang Zhang |
| author_facet | Kurt R. Stover Stellar Lim Terri-Lin Zhou Paul M. Stafford Jonathan Chow Haoyuan Li Nila Sivanenthiran Sivakami Mylvaganam Chiping Wu Donald F. Weaver James Eubanks Liang Zhang |
| author_sort | Kurt R. Stover |
| collection | DOAJ |
| description | The incidence of seizures increases with old age. Stroke, dementia and brain tumors are recognized risk factors for new-onset seizures in the aging populations and the incidence of these conditions also increased with age. Whether aging is associated with higher seizure susceptibility in the absence of the above pathologies remains unclear. We used classic kindling to explore this issue as the kindling model is highly reproducible and allows close monitoring of electrographic and motor seizure activities in individual animals. We kindled male young and aging mice (C57BL/6 strain, 2–3 and 18–22 months of age) via daily hippocampal CA3 stimulation and monitored seizure activity via video and electroencephalographic recordings. The aging mice needed fewer stimuli to evoke stage-5 motor seizures and exhibited longer hippocampal afterdischarges and more frequent hippocampal spikes relative to the young mice, but afterdischarge thresholds and cumulative afterdischarge durations to stage 5 motor seizures were not different between the two age groups. While hippocampal injury and structural alterations at cellular and micro-circuitry levels remain to be examined in the kindled mice, our present observations suggest that susceptibility to hippocampal CA3 kindling seizures is increased with aging in male C57 black mice. |
| first_indexed | 2024-04-12T20:11:41Z |
| format | Article |
| id | doaj.art-c2f5c86ad8ac45fa942ed56c54012e67 |
| institution | Directory Open Access Journal |
| issn | 2451-8301 |
| language | English |
| last_indexed | 2024-04-12T20:11:41Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Reports |
| spelling | doaj.art-c2f5c86ad8ac45fa942ed56c54012e672022-12-22T03:18:14ZengElsevierIBRO Reports2451-83012017-12-013C334410.1016/j.ibror.2017.08.001Susceptibility to hippocampal kindling seizures is increased in aging C57 black miceKurt R. Stover0Stellar Lim1Terri-Lin Zhou2Paul M. Stafford3Jonathan Chow4Haoyuan Li5Nila Sivanenthiran6Sivakami Mylvaganam7Chiping Wu8Donald F. Weaver9James Eubanks10Liang Zhang11Krembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaKrembil Research Institute, University Health Network, CanadaThe incidence of seizures increases with old age. Stroke, dementia and brain tumors are recognized risk factors for new-onset seizures in the aging populations and the incidence of these conditions also increased with age. Whether aging is associated with higher seizure susceptibility in the absence of the above pathologies remains unclear. We used classic kindling to explore this issue as the kindling model is highly reproducible and allows close monitoring of electrographic and motor seizure activities in individual animals. We kindled male young and aging mice (C57BL/6 strain, 2–3 and 18–22 months of age) via daily hippocampal CA3 stimulation and monitored seizure activity via video and electroencephalographic recordings. The aging mice needed fewer stimuli to evoke stage-5 motor seizures and exhibited longer hippocampal afterdischarges and more frequent hippocampal spikes relative to the young mice, but afterdischarge thresholds and cumulative afterdischarge durations to stage 5 motor seizures were not different between the two age groups. While hippocampal injury and structural alterations at cellular and micro-circuitry levels remain to be examined in the kindled mice, our present observations suggest that susceptibility to hippocampal CA3 kindling seizures is increased with aging in male C57 black mice.http://www.sciencedirect.com/science/article/pii/S2451830117300249AgingEEGEpilepsyHippocampusKindlingMice |
| spellingShingle | Kurt R. Stover Stellar Lim Terri-Lin Zhou Paul M. Stafford Jonathan Chow Haoyuan Li Nila Sivanenthiran Sivakami Mylvaganam Chiping Wu Donald F. Weaver James Eubanks Liang Zhang Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice IBRO Reports Aging EEG Epilepsy Hippocampus Kindling Mice |
| title | Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice |
| title_full | Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice |
| title_fullStr | Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice |
| title_full_unstemmed | Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice |
| title_short | Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice |
| title_sort | susceptibility to hippocampal kindling seizures is increased in aging c57 black mice |
| topic | Aging EEG Epilepsy Hippocampus Kindling Mice |
| url | http://www.sciencedirect.com/science/article/pii/S2451830117300249 |
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