Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment
Rheumatoid arthritis (RA) is a complicated autoimmune disease. The clinical applications of etanercept (EN), a TNF-α inhibitor, can efficiently halt the development of RA. EN is mainly administrated by subcutaneous injection, which may cause low compliance, side effects, and infection risk....
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| Format: | Article |
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MDPI AG
2019-05-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/5/235 |
| _version_ | 1828112633500270592 |
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| author | Jian Cao Nan Zhang Ziyi Wang Jingjing Su Jing Yang Jiabing Han Yongxing Zhao |
| author_facet | Jian Cao Nan Zhang Ziyi Wang Jingjing Su Jing Yang Jiabing Han Yongxing Zhao |
| author_sort | Jian Cao |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a complicated autoimmune disease. The clinical applications of etanercept (EN), a TNF-α inhibitor, can efficiently halt the development of RA. EN is mainly administrated by subcutaneous injection, which may cause low compliance, side effects, and infection risk. In this study, a hyaluronic acid crosslinked microneedle system (MN) was constructed as the transdermal alternative to deliver EN. We describe the formulation, fabrication, characterization, and transdermal insertion study of MN. In vitro bioactivity of EN was conducted and analyzed by dynamic light scattering and circular dichroism spectrum. In vivo evaluation of MN was studied on adjuvant-induced arthritis mice. The MN possessed sufficient mechanical strength, good biocompatibility, little influence on the bioactivity of EN, and high anti-inflammatory efficacy. This work represents a successful example of delivering macromolecule therapeutic treatment by MN for RA treatment. The transdermal delivery of EN by MN offers a new treatment option for RA patients. |
| first_indexed | 2024-04-11T11:53:25Z |
| format | Article |
| id | doaj.art-c2f79530f320426196f164888df991a8 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T11:53:25Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c2f79530f320426196f164888df991a82022-12-22T04:25:15ZengMDPI AGPharmaceutics1999-49232019-05-0111523510.3390/pharmaceutics11050235pharmaceutics11050235Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis TreatmentJian Cao0Nan Zhang1Ziyi Wang2Jingjing Su3Jing Yang4Jiabing Han5Yongxing Zhao6Department of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaRheumatoid arthritis (RA) is a complicated autoimmune disease. The clinical applications of etanercept (EN), a TNF-α inhibitor, can efficiently halt the development of RA. EN is mainly administrated by subcutaneous injection, which may cause low compliance, side effects, and infection risk. In this study, a hyaluronic acid crosslinked microneedle system (MN) was constructed as the transdermal alternative to deliver EN. We describe the formulation, fabrication, characterization, and transdermal insertion study of MN. In vitro bioactivity of EN was conducted and analyzed by dynamic light scattering and circular dichroism spectrum. In vivo evaluation of MN was studied on adjuvant-induced arthritis mice. The MN possessed sufficient mechanical strength, good biocompatibility, little influence on the bioactivity of EN, and high anti-inflammatory efficacy. This work represents a successful example of delivering macromolecule therapeutic treatment by MN for RA treatment. The transdermal delivery of EN by MN offers a new treatment option for RA patients.https://www.mdpi.com/1999-4923/11/5/235microneedleetanerceptrheumatoid arthritisdrug deliveryhyaluronic acid |
| spellingShingle | Jian Cao Nan Zhang Ziyi Wang Jingjing Su Jing Yang Jiabing Han Yongxing Zhao Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment Pharmaceutics microneedle etanercept rheumatoid arthritis drug delivery hyaluronic acid |
| title | Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment |
| title_full | Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment |
| title_fullStr | Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment |
| title_full_unstemmed | Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment |
| title_short | Microneedle-Assisted Transdermal Delivery of Etanercept for Rheumatoid Arthritis Treatment |
| title_sort | microneedle assisted transdermal delivery of etanercept for rheumatoid arthritis treatment |
| topic | microneedle etanercept rheumatoid arthritis drug delivery hyaluronic acid |
| url | https://www.mdpi.com/1999-4923/11/5/235 |
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