Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus
Abstract Objective Gene-diet interaction plays a key role in the inter-individual differences in lipid abnormalities as a major risk factor for cardiovascular diseases (CVDs). Thus, we explored the interaction between CETP TaqB1 polymorphism with dietary acid load (DAL) on lipid profile among type 2...
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| Formaat: | Artikel |
| Taal: | English |
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BMC
2023-07-01
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| Reeks: | BMC Endocrine Disorders |
| Onderwerpen: | |
| Online toegang: | https://doi.org/10.1186/s12902-023-01391-6 |
| _version_ | 1827905456504307712 |
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| author | Faezeh Abaj Zahra Esmaeily Zeinab Naeini Ehsan Alvandi Masoumeh Rafiee Fariba Koohdani |
| author_facet | Faezeh Abaj Zahra Esmaeily Zeinab Naeini Ehsan Alvandi Masoumeh Rafiee Fariba Koohdani |
| author_sort | Faezeh Abaj |
| collection | DOAJ |
| description | Abstract Objective Gene-diet interaction plays a key role in the inter-individual differences in lipid abnormalities as a major risk factor for cardiovascular diseases (CVDs). Thus, we explored the interaction between CETP TaqB1 polymorphism with dietary acid load (DAL) on lipid profile among type 2 diabetes mellitus (T2DM). Method This cross-sectional study conducted on 220 Iranian patients with T2DM. Dietary acid load (PRAL and NEAP) was calculated via a validated food-frequency questionnaire (FFQ). The polymerase chain reaction (PCR) used for genotyping Taq1B polymorphism. Biochemical markers were measured by standard protocol. The interaction between CETP Taq1B polymorphism and DAL (PRAL and NEAP) on lipid profile was performed by a generalized linear regression model (GLM). Results The overall prevalence of rs708272 genotypes was 8.6%, 72.7% and 18.6% for B1B1, B1B2 and B2B2 genotype respectively. This study showed that people with the B1B1 genotype had greater LDL, TC, LDL/HDL, and TG when they consumed diets that scored higher on the NEAP and PRAL indexes than those with the B1B2 and B2B2 genotypes. Besides, carriers of the B1B1 allele who were in the highest tertile of NEAP, had lower HDL (P Interaction < 0.05). Conclusions In summary, the lipid profile might be improved in B1B1 homozygotes by less adherence to DAL indexes, however, the findings should be validated in high-quality interventional studies. |
| first_indexed | 2024-03-13T00:41:55Z |
| format | Article |
| id | doaj.art-c2f90dc520ea4b1597f89b51e56c57c4 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-13T00:41:55Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-c2f90dc520ea4b1597f89b51e56c57c42023-07-09T11:16:11ZengBMCBMC Endocrine Disorders1472-68232023-07-0123111010.1186/s12902-023-01391-6Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitusFaezeh Abaj0Zahra Esmaeily1Zeinab Naeini2Ehsan Alvandi3Masoumeh Rafiee4Fariba Koohdani5Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesSchool of Medicine, Western Sydney UniversityDepartment of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences (IUMS)Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesAbstract Objective Gene-diet interaction plays a key role in the inter-individual differences in lipid abnormalities as a major risk factor for cardiovascular diseases (CVDs). Thus, we explored the interaction between CETP TaqB1 polymorphism with dietary acid load (DAL) on lipid profile among type 2 diabetes mellitus (T2DM). Method This cross-sectional study conducted on 220 Iranian patients with T2DM. Dietary acid load (PRAL and NEAP) was calculated via a validated food-frequency questionnaire (FFQ). The polymerase chain reaction (PCR) used for genotyping Taq1B polymorphism. Biochemical markers were measured by standard protocol. The interaction between CETP Taq1B polymorphism and DAL (PRAL and NEAP) on lipid profile was performed by a generalized linear regression model (GLM). Results The overall prevalence of rs708272 genotypes was 8.6%, 72.7% and 18.6% for B1B1, B1B2 and B2B2 genotype respectively. This study showed that people with the B1B1 genotype had greater LDL, TC, LDL/HDL, and TG when they consumed diets that scored higher on the NEAP and PRAL indexes than those with the B1B2 and B2B2 genotypes. Besides, carriers of the B1B1 allele who were in the highest tertile of NEAP, had lower HDL (P Interaction < 0.05). Conclusions In summary, the lipid profile might be improved in B1B1 homozygotes by less adherence to DAL indexes, however, the findings should be validated in high-quality interventional studies.https://doi.org/10.1186/s12902-023-01391-6CETP polymorphismT2DMNutrigeneticDietary acid load |
| spellingShingle | Faezeh Abaj Zahra Esmaeily Zeinab Naeini Ehsan Alvandi Masoumeh Rafiee Fariba Koohdani Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus BMC Endocrine Disorders CETP polymorphism T2DM Nutrigenetic Dietary acid load |
| title | Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus |
| title_full | Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus |
| title_fullStr | Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus |
| title_full_unstemmed | Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus |
| title_short | Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus |
| title_sort | dietary acid load and its interaction with cetp taqb1 polymorphisms on lipid profile among patients with type 2 diabetes mellitus |
| topic | CETP polymorphism T2DM Nutrigenetic Dietary acid load |
| url | https://doi.org/10.1186/s12902-023-01391-6 |
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