Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005
<p>Abstract</p> <p>Background</p> <p>Between 1992 and 2001 the UK general practice incidence of post-herpetic neuralgia and trigeminal neuralgia declined, whilst the incidence of painful diabetic neuropathy increased. The most common first line treatments were compound...
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| Format: | Article |
| Language: | English |
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BMC
2008-05-01
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| Series: | BMC Family Practice |
| Online Access: | http://www.biomedcentral.com/1471-2296/9/26 |
| _version_ | 1829460371224657920 |
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| author | Carroll Dawn Hall Gillian C McQuay Henry J |
| author_facet | Carroll Dawn Hall Gillian C McQuay Henry J |
| author_sort | Carroll Dawn |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Between 1992 and 2001 the UK general practice incidence of post-herpetic neuralgia and trigeminal neuralgia declined, whilst the incidence of painful diabetic neuropathy increased. The most common first line treatments were compound analgesics. As therapeutic options have subsequently changed, this study presents updated data on incidence and prescribing patterns in neuropathic pain.</p> <p>Methods</p> <p>A descriptive analysis of the epidemiology and prescription treatment at diagnosis of incident post-herpetic neuralgia (n = 1,923); trigeminal neuralgia (1,862); phantom limb pain (57) and painful diabetic neuropathy (1,444) using computerised UK general practice records (THIN): May 2002 to July 2005.</p> <p>Results</p> <p>Primary care incidences per 100,000 person years observation of 28 (95% confidence interval (CI) 27–30) for post-herpetic neuralgia, 27 (95%CI 26–29) for trigeminal neuralgia, 0.8 (95%CI 0.6–1.1) for phantom limb pain and 21 (95%CI 20–22) for painful diabetic neuropathy are reported. The most common initial treatments were tricyclic antidepressants (post-herpetic neuralgia) or antiepileptics (trigeminal neuralgia and painful diabetic neuropathy) and opioid analgesics (phantom limb pain). The mean number of changes before a stable drug regimen was 1.2 to 1.5 for trigeminal neuralgia, painful diabetic neuropathy and post-herpetic neuralgia, and 2.4 for phantom limb pain.</p> <p>Conclusion</p> <p>The incidence of phantom limb pain and post-herpetic neuralgia are decreasing whilst painful diabetic neuropathy plateaued and trigeminal neuralgia remained constant. Despite more frequent use of antidepressants and antiepileptics for first line treatment, as opposed to conventional non-opioid analgesics, changes to therapy are common before a stable regimen is reached.</p> |
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| id | doaj.art-c2f9854207c745b8b628f105e264e1f8 |
| institution | Directory Open Access Journal |
| issn | 1471-2296 |
| language | English |
| last_indexed | 2024-12-12T11:32:31Z |
| publishDate | 2008-05-01 |
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| series | BMC Family Practice |
| spelling | doaj.art-c2f9854207c745b8b628f105e264e1f82022-12-22T00:25:45ZengBMCBMC Family Practice1471-22962008-05-01912610.1186/1471-2296-9-26Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005Carroll DawnHall Gillian CMcQuay Henry J<p>Abstract</p> <p>Background</p> <p>Between 1992 and 2001 the UK general practice incidence of post-herpetic neuralgia and trigeminal neuralgia declined, whilst the incidence of painful diabetic neuropathy increased. The most common first line treatments were compound analgesics. As therapeutic options have subsequently changed, this study presents updated data on incidence and prescribing patterns in neuropathic pain.</p> <p>Methods</p> <p>A descriptive analysis of the epidemiology and prescription treatment at diagnosis of incident post-herpetic neuralgia (n = 1,923); trigeminal neuralgia (1,862); phantom limb pain (57) and painful diabetic neuropathy (1,444) using computerised UK general practice records (THIN): May 2002 to July 2005.</p> <p>Results</p> <p>Primary care incidences per 100,000 person years observation of 28 (95% confidence interval (CI) 27–30) for post-herpetic neuralgia, 27 (95%CI 26–29) for trigeminal neuralgia, 0.8 (95%CI 0.6–1.1) for phantom limb pain and 21 (95%CI 20–22) for painful diabetic neuropathy are reported. The most common initial treatments were tricyclic antidepressants (post-herpetic neuralgia) or antiepileptics (trigeminal neuralgia and painful diabetic neuropathy) and opioid analgesics (phantom limb pain). The mean number of changes before a stable drug regimen was 1.2 to 1.5 for trigeminal neuralgia, painful diabetic neuropathy and post-herpetic neuralgia, and 2.4 for phantom limb pain.</p> <p>Conclusion</p> <p>The incidence of phantom limb pain and post-herpetic neuralgia are decreasing whilst painful diabetic neuropathy plateaued and trigeminal neuralgia remained constant. Despite more frequent use of antidepressants and antiepileptics for first line treatment, as opposed to conventional non-opioid analgesics, changes to therapy are common before a stable regimen is reached.</p>http://www.biomedcentral.com/1471-2296/9/26 |
| spellingShingle | Carroll Dawn Hall Gillian C McQuay Henry J Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005 BMC Family Practice |
| title | Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005 |
| title_full | Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005 |
| title_fullStr | Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005 |
| title_full_unstemmed | Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005 |
| title_short | Primary care incidence and treatment of four neuropathic pain conditions: A descriptive study, 2002–2005 |
| title_sort | primary care incidence and treatment of four neuropathic pain conditions a descriptive study 2002 2005 |
| url | http://www.biomedcentral.com/1471-2296/9/26 |
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