Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration
Abstact Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types, growth factors, extracellular matrix (ECM), nerves, and blood vessels. Mesenchymal stromal cells (MSCs) take part in al...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2019-12-01
|
| Series: | Burns & Trauma |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41038-019-0178-8 |
| _version_ | 1828866637119356928 |
|---|---|
| author | Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato Ilaria Dal Prà Anna Chiarini |
| author_facet | Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato Ilaria Dal Prà Anna Chiarini |
| author_sort | Peng Hu |
| collection | DOAJ |
| description | Abstact Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types, growth factors, extracellular matrix (ECM), nerves, and blood vessels. Mesenchymal stromal cells (MSCs) take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans. Exosomes, which are among the key products MSCs release, mimic the effects of parental MSCs. They can shuttle various effector proteins, messenger RNA (mRNA) and microRNAs (miRNAs) to modulate the activity of recipient cells, playing important roles in wound healing. Moreover, using exosomes avoids many risks associated with cell transplantation. Therefore, as a novel type of cell-free therapy, MSC-exosome -mediated administration may be safer and more efficient than whole cell. In this review, we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration. In addition, we address the hypothesis of MSCs microenvironment extracellular vesicles (MSCs-MEVs) or MSCs microenvironment exosomes (MSCs-MExos) that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications. This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration. |
| first_indexed | 2024-12-13T04:53:59Z |
| format | Article |
| id | doaj.art-c2faa30092984c9ba5a6b31f91ddd08f |
| institution | Directory Open Access Journal |
| issn | 2321-3876 |
| language | English |
| last_indexed | 2024-12-13T04:53:59Z |
| publishDate | 2019-12-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Burns & Trauma |
| spelling | doaj.art-c2faa30092984c9ba5a6b31f91ddd08f2022-12-21T23:58:56ZengOxford University PressBurns & Trauma2321-38762019-12-017111010.1186/s41038-019-0178-8Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regenerationPeng Hu0Qinxin Yang1Qi Wang2Chenshuo Shi3Dali Wang4Ubaldo Armato5Ilaria Dal Prà6Anna Chiarini7Department of Burns & Plastic Surgery, The Affiliated Hospital of ZunYi Medical UniversityDepartment of Burns & Plastic Surgery, The Affiliated Hospital of ZunYi Medical UniversityDepartment of Burns & Plastic Surgery, The Affiliated Hospital of ZunYi Medical UniversityDepartment of Burns & Plastic Surgery, The Affiliated Hospital of ZunYi Medical UniversityDepartment of Burns & Plastic Surgery, The Affiliated Hospital of ZunYi Medical UniversityHuman Histology and Embryology Unit, University of Verona Medical SchoolHuman Histology and Embryology Unit, University of Verona Medical SchoolHuman Histology and Embryology Unit, University of Verona Medical SchoolAbstact Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types, growth factors, extracellular matrix (ECM), nerves, and blood vessels. Mesenchymal stromal cells (MSCs) take part in all the skin wound healing stages playing active and beneficial roles in animal models and humans. Exosomes, which are among the key products MSCs release, mimic the effects of parental MSCs. They can shuttle various effector proteins, messenger RNA (mRNA) and microRNAs (miRNAs) to modulate the activity of recipient cells, playing important roles in wound healing. Moreover, using exosomes avoids many risks associated with cell transplantation. Therefore, as a novel type of cell-free therapy, MSC-exosome -mediated administration may be safer and more efficient than whole cell. In this review, we provide a comprehensive understanding of the latest studies and observations on the role of MSC-exosome therapy in wound healing and cutaneous regeneration. In addition, we address the hypothesis of MSCs microenvironment extracellular vesicles (MSCs-MEVs) or MSCs microenvironment exosomes (MSCs-MExos) that need to take stock of and solved urgently in the related research about MSC-exosomes therapeutic applications. This review can inspire investigators to explore new research directions of MSC-exosome therapy in cutaneous repair and regeneration.http://link.springer.com/article/10.1186/s41038-019-0178-8Cutaneous regenerationMesenchymal stromal cellExosomesWound healingMicroenvironment |
| spellingShingle | Peng Hu Qinxin Yang Qi Wang Chenshuo Shi Dali Wang Ubaldo Armato Ilaria Dal Prà Anna Chiarini Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration Burns & Trauma Cutaneous regeneration Mesenchymal stromal cell Exosomes Wound healing Microenvironment |
| title | Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration |
| title_full | Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration |
| title_fullStr | Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration |
| title_full_unstemmed | Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration |
| title_short | Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration |
| title_sort | mesenchymal stromal cells exosomes a promising cell free therapeutic tool for wound healing and cutaneous regeneration |
| topic | Cutaneous regeneration Mesenchymal stromal cell Exosomes Wound healing Microenvironment |
| url | http://link.springer.com/article/10.1186/s41038-019-0178-8 |
| work_keys_str_mv | AT penghu mesenchymalstromalcellsexosomesapromisingcellfreetherapeutictoolforwoundhealingandcutaneousregeneration AT qinxinyang mesenchymalstromalcellsexosomesapromisingcellfreetherapeutictoolforwoundhealingandcutaneousregeneration AT qiwang mesenchymalstromalcellsexosomesapromisingcellfreetherapeutictoolforwoundhealingandcutaneousregeneration AT chenshuoshi mesenchymalstromalcellsexosomesapromisingcellfreetherapeutictoolforwoundhealingandcutaneousregeneration AT daliwang mesenchymalstromalcellsexosomesapromisingcellfreetherapeutictoolforwoundhealingandcutaneousregeneration AT ubaldoarmato mesenchymalstromalcellsexosomesapromisingcellfreetherapeutictoolforwoundhealingandcutaneousregeneration AT ilariadalpra mesenchymalstromalcellsexosomesapromisingcellfreetherapeutictoolforwoundhealingandcutaneousregeneration AT annachiarini mesenchymalstromalcellsexosomesapromisingcellfreetherapeutictoolforwoundhealingandcutaneousregeneration |