Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy

Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy

Considerable developments have been observed in fragment-based lead/drug discovery (FBLD/FBDD) recently, with four drugs approved and many others under investigation. Nuclear magnetic resonance (NMR) has gained increasing popularity in FBLD due to its intrinsic capability in characterizing protein-l...

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Bibliographic Details
Main Authors: Lei Wang, Jia Gao, Rongsheng Ma, Yaqian Liu, Mingqing Liu, Fumei Zhong, Jie Hu, Shuju Li, Jihui Wu, Hualiang Jiang, Jiahai Zhang, Ke Ruan
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2022-05-01
Series:Magnetic Resonance Letters
Subjects:
Fragment-based lead/drug discovery
NMR spectroscopy
Protein-ligand interaction
Complex structure
Hit-to-lead evolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2772516221000255

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