High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study
Abstract Background The accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalence of DM and preDM in TB affected people in Lima, Peru. Methods A prospe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-09-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4416-2 |
| _version_ | 1818271531972689920 |
|---|---|
| author | Roger I. Calderon Maria B. Arriaga Kattya Lopez Nadia N. Barreda Oswaldo M. Sanabria José F. Fróes Neto Davi Neri Araújo Leonid Lecca Bruno B. Andrade |
| author_facet | Roger I. Calderon Maria B. Arriaga Kattya Lopez Nadia N. Barreda Oswaldo M. Sanabria José F. Fróes Neto Davi Neri Araújo Leonid Lecca Bruno B. Andrade |
| author_sort | Roger I. Calderon |
| collection | DOAJ |
| description | Abstract Background The accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalence of DM and preDM in TB affected people in Lima, Peru. Methods A prospective cohort study of patients affected TB and their household contacts (HHC), was conducted between February and November 2017 in Lima, Peru. Fasting plasma glucose (FPG), HbA1c and oral glucose tolerance test (OGTT) were used to detect DM and preDM in a prospective cohort of TB patients (n = 136) and household contacts (n = 138). Diagnostic performance of the laboratory tests was analyzed. Potential effects of sociodemographic and clinical factors on detection of dysglycemia were analyzed. Results In TB patients, prevalence of DM and preDM was 13.97 and 30.88% respectively. Lower prevalence of both DM (6.52%) and preDM (28.99%) were observed in contacts. FPG, HbA1c and OGTT had poor agreement in detection of preDM in either TB cases or contacts. TB-DM patients had substantially lower hemoglobin levels, which resulted in low accuracy of HbA1c-based diagnosis. Classic sociodemographic and clinical characteristics were not different between TB patients with or without dysglycemia. Conclusion High prevalence of DM and preDM was found in both TB patients and contacts in Lima. Anemia was strongly associated with TB-DM, which directly affected the diagnostic performance of HbA1c in such population. |
| first_indexed | 2024-12-12T21:27:40Z |
| format | Article |
| id | doaj.art-c2fcc437c2984b1c861b8ae8ec2a39c1 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T21:27:40Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-c2fcc437c2984b1c861b8ae8ec2a39c12022-12-22T00:11:25ZengBMCBMC Infectious Diseases1471-23342019-09-0119111110.1186/s12879-019-4416-2High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort studyRoger I. Calderon0Maria B. Arriaga1Kattya Lopez2Nadia N. Barreda3Oswaldo M. Sanabria4José F. Fróes Neto5Davi Neri Araújo6Leonid Lecca7Bruno B. Andrade8Socios En Salud Sucursal PeruFaculdade de Medicina, Universidade Federal da BahiaSocios En Salud Sucursal PeruSocios En Salud Sucursal PeruSocios En Salud Sucursal PeruMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José SilveiraFaculdade de Medicina, Universidade Federal da BahiaSocios En Salud Sucursal PeruFaculdade de Medicina, Universidade Federal da BahiaAbstract Background The accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalence of DM and preDM in TB affected people in Lima, Peru. Methods A prospective cohort study of patients affected TB and their household contacts (HHC), was conducted between February and November 2017 in Lima, Peru. Fasting plasma glucose (FPG), HbA1c and oral glucose tolerance test (OGTT) were used to detect DM and preDM in a prospective cohort of TB patients (n = 136) and household contacts (n = 138). Diagnostic performance of the laboratory tests was analyzed. Potential effects of sociodemographic and clinical factors on detection of dysglycemia were analyzed. Results In TB patients, prevalence of DM and preDM was 13.97 and 30.88% respectively. Lower prevalence of both DM (6.52%) and preDM (28.99%) were observed in contacts. FPG, HbA1c and OGTT had poor agreement in detection of preDM in either TB cases or contacts. TB-DM patients had substantially lower hemoglobin levels, which resulted in low accuracy of HbA1c-based diagnosis. Classic sociodemographic and clinical characteristics were not different between TB patients with or without dysglycemia. Conclusion High prevalence of DM and preDM was found in both TB patients and contacts in Lima. Anemia was strongly associated with TB-DM, which directly affected the diagnostic performance of HbA1c in such population.http://link.springer.com/article/10.1186/s12879-019-4416-2Diabetes mellitusPrediabetesTuberculosisComorbidityPrevalence |
| spellingShingle | Roger I. Calderon Maria B. Arriaga Kattya Lopez Nadia N. Barreda Oswaldo M. Sanabria José F. Fróes Neto Davi Neri Araújo Leonid Lecca Bruno B. Andrade High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study BMC Infectious Diseases Diabetes mellitus Prediabetes Tuberculosis Comorbidity Prevalence |
| title | High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study |
| title_full | High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study |
| title_fullStr | High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study |
| title_full_unstemmed | High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study |
| title_short | High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study |
| title_sort | high prevalence and heterogeneity of dysglycemia in patients with tuberculosis from peru a prospective cohort study |
| topic | Diabetes mellitus Prediabetes Tuberculosis Comorbidity Prevalence |
| url | http://link.springer.com/article/10.1186/s12879-019-4416-2 |
| work_keys_str_mv | AT rogericalderon highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy AT mariabarriaga highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy AT kattyalopez highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy AT nadianbarreda highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy AT oswaldomsanabria highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy AT joseffroesneto highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy AT davineriaraujo highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy AT leonidlecca highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy AT brunobandrade highprevalenceandheterogeneityofdysglycemiainpatientswithtuberculosisfromperuaprospectivecohortstudy |