Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode
This study was conducted to compare the response rate of Quetiapine and Haloperidol in patients with acute manic episodes. A total of 120 patients with acute episode of mania with baseline Young Mania Rating Scale (YMRS) of more than 20 were included and randomly allocated to either Quetiapine (Gro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pakistan Medical Association
2022-03-01
|
| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/3266 |
| _version_ | 1797820812411011072 |
|---|---|
| author | Noman Khan Usama Bin Zubair Saad Ali Khan Junaid Ul Islam Syed Azhar Ali Kazmi Abrar Khan |
| author_facet | Noman Khan Usama Bin Zubair Saad Ali Khan Junaid Ul Islam Syed Azhar Ali Kazmi Abrar Khan |
| author_sort | Noman Khan |
| collection | DOAJ |
| description |
This study was conducted to compare the response rate of Quetiapine and Haloperidol in patients with acute manic episodes. A total of 120 patients with acute episode of mania with baseline Young Mania Rating Scale (YMRS) of more than 20 were included and randomly allocated to either Quetiapine (Group A) or Haloperidol (Group B). Each patient was assessed at baseline. YMRS was administered at the start and at follow-up visit after six weeks. Comparison of response rate (>50% reduction in YMRS) was not statistically significant between the two groups (70% vs. 71.7%; p=0.410) after six weeks in acute manic episode. Quetiapine and Haloperidol emerged as equally effective pharmacological strategies for the treatment of bipolar mania. Quetiapine may be used as an alternative to conventional antipsychotics; Haloperidol can be used as replacement of Quetiapine as well, as it is of low cost.
Key Words: Acute manic episode; Quetiapine; Haloperidol
|
| first_indexed | 2024-03-13T09:43:52Z |
| format | Article |
| id | doaj.art-c2ff5f8b31b64c92ab0eac1411b1198f |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T09:43:52Z |
| publishDate | 2022-03-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-c2ff5f8b31b64c92ab0eac1411b1198f2023-05-25T04:22:36ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822022-03-0172810.47391/JPMA.3266Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episodeNoman Khan0Usama Bin Zubair 1Saad Ali Khan 2Junaid Ul Islam 3Syed Azhar Ali Kazmi4Abrar Khan 5Department of Psychiatry, Saidu Group of Teaching Hospital, Swat, PakistanDepartment of Psychiatry, Connoly Hospital, Dublin, IrelandDepartment of Psychiatry, Fauji Foundation Hospital, Rawalpindi, PakistanDepartment of Psychiatry, Pakistan Institute of Medical Sciences , Islamabad, PakistanDepartment of Psychiatry, Poonch Medical College, Rawalkot, PakistanDepartment of Psychiatry, Saidu Group of Teaching Hospital, Swat, Pakistan This study was conducted to compare the response rate of Quetiapine and Haloperidol in patients with acute manic episodes. A total of 120 patients with acute episode of mania with baseline Young Mania Rating Scale (YMRS) of more than 20 were included and randomly allocated to either Quetiapine (Group A) or Haloperidol (Group B). Each patient was assessed at baseline. YMRS was administered at the start and at follow-up visit after six weeks. Comparison of response rate (>50% reduction in YMRS) was not statistically significant between the two groups (70% vs. 71.7%; p=0.410) after six weeks in acute manic episode. Quetiapine and Haloperidol emerged as equally effective pharmacological strategies for the treatment of bipolar mania. Quetiapine may be used as an alternative to conventional antipsychotics; Haloperidol can be used as replacement of Quetiapine as well, as it is of low cost. Key Words: Acute manic episode; Quetiapine; Haloperidol https://www.ojs.jpma.org.pk/index.php/public_html/article/view/3266 |
| spellingShingle | Noman Khan Usama Bin Zubair Saad Ali Khan Junaid Ul Islam Syed Azhar Ali Kazmi Abrar Khan Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode Journal of the Pakistan Medical Association |
| title | Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode |
| title_full | Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode |
| title_fullStr | Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode |
| title_full_unstemmed | Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode |
| title_short | Comparison of effectiveness between Haloperidol and Quetiapine in acute manic episode |
| title_sort | comparison of effectiveness between haloperidol and quetiapine in acute manic episode |
| url | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/3266 |
| work_keys_str_mv | AT nomankhan comparisonofeffectivenessbetweenhaloperidolandquetiapineinacutemanicepisode AT usamabinzubair comparisonofeffectivenessbetweenhaloperidolandquetiapineinacutemanicepisode AT saadalikhan comparisonofeffectivenessbetweenhaloperidolandquetiapineinacutemanicepisode AT junaidulislam comparisonofeffectivenessbetweenhaloperidolandquetiapineinacutemanicepisode AT syedazharalikazmi comparisonofeffectivenessbetweenhaloperidolandquetiapineinacutemanicepisode AT abrarkhan comparisonofeffectivenessbetweenhaloperidolandquetiapineinacutemanicepisode |