Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report
ObjectiveTo compare survival outcomes of type B radical hysterectomy (RH) and type C RH in patients with early-stage cervical cancer.MethodsWe retrospectively identified continuous cervical cancer patients with FIGO stage IA2-IB2 and IIA1 who underwent either type B RH (n = 278) or type C RH (n = 14...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1166084/full |
| _version_ | 1797848201060941824 |
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| author | Lu Wang Ping Liu Hui Duan Pengfei Li Guidong Su Weili Li Cong Liang Chunlin Chen |
| author_facet | Lu Wang Ping Liu Hui Duan Pengfei Li Guidong Su Weili Li Cong Liang Chunlin Chen |
| author_sort | Lu Wang |
| collection | DOAJ |
| description | ObjectiveTo compare survival outcomes of type B radical hysterectomy (RH) and type C RH in patients with early-stage cervical cancer.MethodsWe retrospectively identified continuous cervical cancer patients with FIGO stage IA2-IB2 and IIA1 who underwent either type B RH (n = 278) or type C RH (n = 148) performed by the same group of surgeons between 2009 and 2018. Propensity score matching was carried out to minimize selection biases. Intraoperative photographs, immediate postoperative questionnaire and specimen measurements were used to accurately determine the extensive of surgery. We further narrowed the study population to patients with specific histological subtypes and patients with deep stromal invasion.ResultsThe median follow-up period was 42.41 ± 24.60 months. After adjusting, no differences in the 5-year overall survival (OS) and disease-free survival (DFS) were found between the type B group and the type C group (OS: 87.8% vs. 89.4%, P = 0.814; DFS: 84.9% vs. 85.6%, P = 0.898). In further analysis of patients with squamous-cell carcinoma, adenocarcinoma, adenosquamous carcinoma, similar 5-year OS and DFS rates were found between two groups (OS: 88.7% vs. 97.1%, P = 0.250; DFS: 84.7% vs. 92.3%, P = 0.541). Consistent results were found in patients with deep stromal invasion (OS: 81.8% vs. 100%, P = 0.144; DFS: 82.8% vs. 100%, P = 0.128).ConclusionsType B RH could be used to treat FIGO stage IA2-IB2 and IIA1 cervical cancer to get equivalent 5-year OS and DFS. Further randomized controlled trials are warranted. |
| first_indexed | 2024-04-09T18:24:41Z |
| format | Article |
| id | doaj.art-c2ff84ad966b431bbb0ff02e3bf3fa71 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-09T18:24:41Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-c2ff84ad966b431bbb0ff02e3bf3fa712023-04-12T05:22:44ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-04-011010.3389/fsurg.2023.11660841166084Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort reportLu WangPing LiuHui DuanPengfei LiGuidong SuWeili LiCong LiangChunlin ChenObjectiveTo compare survival outcomes of type B radical hysterectomy (RH) and type C RH in patients with early-stage cervical cancer.MethodsWe retrospectively identified continuous cervical cancer patients with FIGO stage IA2-IB2 and IIA1 who underwent either type B RH (n = 278) or type C RH (n = 148) performed by the same group of surgeons between 2009 and 2018. Propensity score matching was carried out to minimize selection biases. Intraoperative photographs, immediate postoperative questionnaire and specimen measurements were used to accurately determine the extensive of surgery. We further narrowed the study population to patients with specific histological subtypes and patients with deep stromal invasion.ResultsThe median follow-up period was 42.41 ± 24.60 months. After adjusting, no differences in the 5-year overall survival (OS) and disease-free survival (DFS) were found between the type B group and the type C group (OS: 87.8% vs. 89.4%, P = 0.814; DFS: 84.9% vs. 85.6%, P = 0.898). In further analysis of patients with squamous-cell carcinoma, adenocarcinoma, adenosquamous carcinoma, similar 5-year OS and DFS rates were found between two groups (OS: 88.7% vs. 97.1%, P = 0.250; DFS: 84.7% vs. 92.3%, P = 0.541). Consistent results were found in patients with deep stromal invasion (OS: 81.8% vs. 100%, P = 0.144; DFS: 82.8% vs. 100%, P = 0.128).ConclusionsType B RH could be used to treat FIGO stage IA2-IB2 and IIA1 cervical cancer to get equivalent 5-year OS and DFS. Further randomized controlled trials are warranted.https://www.frontiersin.org/articles/10.3389/fsurg.2023.1166084/fullcervical cancerearly-stagetype b radical hysterectomysurvival outcomeparametrectomy |
| spellingShingle | Lu Wang Ping Liu Hui Duan Pengfei Li Guidong Su Weili Li Cong Liang Chunlin Chen Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report Frontiers in Surgery cervical cancer early-stage type b radical hysterectomy survival outcome parametrectomy |
| title | Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report |
| title_full | Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report |
| title_fullStr | Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report |
| title_full_unstemmed | Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report |
| title_short | Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report |
| title_sort | abdominal type b vs type c radical hysterectomy in early stage cervical cancer a matched single center cohort report |
| topic | cervical cancer early-stage type b radical hysterectomy survival outcome parametrectomy |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2023.1166084/full |
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