COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes
Newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) pandemic has now spread across the globe in past few months while affecting 26 million people and leading to more than 0.85 million deaths as on 2nd September, 2020. Severity of SA...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2020-09-01
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| Series: | Journal of Pure and Applied Microbiology |
| Subjects: | |
| Online Access: | https://microbiologyjournal.org/covid-19-and-the-world-with-co-morbidities-of-heart-disease-hypertension-and-diabetes/ |
| _version_ | 1818903002086375424 |
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| author | Vijaya Anand Arumugam Sangeetha Thangavelu Zareena Fathah Pavithra Ravindran Ann Mary Alappat Sanjeev Sunantha Babu Arun Meyyazhagan Mohd. Iqbal Yatoo Khan Sharun Ruchi Tiwari Megha Katare Pandey Ranjit Sah Ram Chandra Kuldeep Dhama |
| author_facet | Vijaya Anand Arumugam Sangeetha Thangavelu Zareena Fathah Pavithra Ravindran Ann Mary Alappat Sanjeev Sunantha Babu Arun Meyyazhagan Mohd. Iqbal Yatoo Khan Sharun Ruchi Tiwari Megha Katare Pandey Ranjit Sah Ram Chandra Kuldeep Dhama |
| author_sort | Vijaya Anand Arumugam |
| collection | DOAJ |
| description | Newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) pandemic has now spread across the globe in past few months while affecting 26 million people and leading to more than 0.85 million deaths as on 2nd September, 2020. Severity of SARS-CoV-2 infection increases in COVID-19 patients due to pre-existing health co-morbidities. This mini-review has focused on the three significant co-morbidities viz., heart disease, hypertension, and diabetes, which are posing high health concerns and increased mortality during this ongoing pandemic. The observed co-morbidities have been found to be associated with the increasing risk factors for SARS-CoV-2 infection and COVID-19 critical illness as well as to be associated positively with the worsening of the health condition of COVID-19 suffering individuals resulting in the high risk for mortality. SARS-CoV-2 enters host cell via angiotensin-converting enzyme 2 receptors. Regulation of crucial cardiovascular functions and metabolisms like blood pressure and sugar levels are being carried out by ACE2. This might be one of the reasons that contribute to the higher mortality in COVID-19 patients having co-morbidities. Clinical investigations have identified higher levels of creatinine, cardiac troponin I, alanine aminotransferase, NT-proBNP, creatine kinase, D-dimer, aspartate aminotransferase and lactate dehydrogenase in patients who have succumbed to death from COVID-19 as compared to recovered individuals. More investigations are required to identify the modes behind increased mortality in COVID-19 patients having co-morbidities of heart disease, hypertension, and diabetes. This will enable us to design and develop suitable therapeutic strategies for reducing the mortality. More attention and critical care need to be paid to such high risk patients suffering from co-morbidities during COVID-19 pandemic. |
| first_indexed | 2024-12-19T20:44:37Z |
| format | Article |
| id | doaj.art-c2ff991fcde4452faeb34dc73cf90f00 |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-12-19T20:44:37Z |
| publishDate | 2020-09-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-c2ff991fcde4452faeb34dc73cf90f002022-12-21T20:06:17ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2020-09-011431623163810.22207/JPAM.14.3.01COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and DiabetesVijaya Anand Arumugamhttps://orcid.org/0000-0001-7485-1586Sangeetha Thangaveluhttps://orcid.org/0000-0002-5069-6304Zareena Fathahhttps://orcid.org/0000-0001-8824-0372Pavithra RavindranAnn Mary Alappat SanjeevSunantha BabuArun Meyyazhaganhttps://orcid.org/0000-0002-1934-3906Mohd. Iqbal Yatoohttps://orcid.org/0000-0002-4501-7354Khan Sharunhttps://orcid.org/0000-0003-1040-3746Ruchi Tiwarihttps://orcid.org/0000-0001-7763-5547Megha Katare PandeyRanjit Sahhttps://orcid.org/0000-0002-2695-8714Ram Chandrahttps://orcid.org/0000-0002-0492-8549Kuldeep Dhamahttps://orcid.org/0000-0001-7469-4752Newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) pandemic has now spread across the globe in past few months while affecting 26 million people and leading to more than 0.85 million deaths as on 2nd September, 2020. Severity of SARS-CoV-2 infection increases in COVID-19 patients due to pre-existing health co-morbidities. This mini-review has focused on the three significant co-morbidities viz., heart disease, hypertension, and diabetes, which are posing high health concerns and increased mortality during this ongoing pandemic. The observed co-morbidities have been found to be associated with the increasing risk factors for SARS-CoV-2 infection and COVID-19 critical illness as well as to be associated positively with the worsening of the health condition of COVID-19 suffering individuals resulting in the high risk for mortality. SARS-CoV-2 enters host cell via angiotensin-converting enzyme 2 receptors. Regulation of crucial cardiovascular functions and metabolisms like blood pressure and sugar levels are being carried out by ACE2. This might be one of the reasons that contribute to the higher mortality in COVID-19 patients having co-morbidities. Clinical investigations have identified higher levels of creatinine, cardiac troponin I, alanine aminotransferase, NT-proBNP, creatine kinase, D-dimer, aspartate aminotransferase and lactate dehydrogenase in patients who have succumbed to death from COVID-19 as compared to recovered individuals. More investigations are required to identify the modes behind increased mortality in COVID-19 patients having co-morbidities of heart disease, hypertension, and diabetes. This will enable us to design and develop suitable therapeutic strategies for reducing the mortality. More attention and critical care need to be paid to such high risk patients suffering from co-morbidities during COVID-19 pandemic.https://microbiologyjournal.org/covid-19-and-the-world-with-co-morbidities-of-heart-disease-hypertension-and-diabetes/sars-cov-2covid-19heart diseasehypertensiondiabetespandemicco-morbidity |
| spellingShingle | Vijaya Anand Arumugam Sangeetha Thangavelu Zareena Fathah Pavithra Ravindran Ann Mary Alappat Sanjeev Sunantha Babu Arun Meyyazhagan Mohd. Iqbal Yatoo Khan Sharun Ruchi Tiwari Megha Katare Pandey Ranjit Sah Ram Chandra Kuldeep Dhama COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes Journal of Pure and Applied Microbiology sars-cov-2 covid-19 heart disease hypertension diabetes pandemic co-morbidity |
| title | COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes |
| title_full | COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes |
| title_fullStr | COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes |
| title_full_unstemmed | COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes |
| title_short | COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes |
| title_sort | covid 19 and the world with co morbidities of heart disease hypertension and diabetes |
| topic | sars-cov-2 covid-19 heart disease hypertension diabetes pandemic co-morbidity |
| url | https://microbiologyjournal.org/covid-19-and-the-world-with-co-morbidities-of-heart-disease-hypertension-and-diabetes/ |
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