18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence
Abstract Glucose utilization by visceral adipose tissue (VAT) reflects inflammatory activity, which also promotes tumor growth and carcinogenesis. The effect of metabolically active VAT on survival outcomes in breast cancer is unknown. We investigated survival outcomes in patients with breast cancer...
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25540-4 |
| _version_ | 1811302033207066624 |
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| author | Hyun Jeong Kim Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Woo-Chan Park Young Hoon Ryu Tae Joo Jeon Yangkyu Lee Yoon Jin Cha Chang Ik Yoon |
| author_facet | Hyun Jeong Kim Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Woo-Chan Park Young Hoon Ryu Tae Joo Jeon Yangkyu Lee Yoon Jin Cha Chang Ik Yoon |
| author_sort | Hyun Jeong Kim |
| collection | DOAJ |
| description | Abstract Glucose utilization by visceral adipose tissue (VAT) reflects inflammatory activity, which also promotes tumor growth and carcinogenesis. The effect of metabolically active VAT on survival outcomes in breast cancer is unknown. We investigated survival outcomes in patients with breast cancer based on the standardized uptake value (SUV) of VAT (SUVmean-VAT) using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). A total of 148 patients with breast cancer were divided into high- and low groups according to their SUVmean-VAT and SUVmax-tumor. Clinical characteristics and survival outcomes were compared between the groups. High SUVmean-VAT was associated with poor recurrence-free survival (RFS; hazard ratio [HR], 2.754; 95% confidence interval [CI], 1.090–6.958, p = 0.032) and distant metastasis-free survival (DMFS; HR, 3.500; 95% CI, 1.224–10.01, p = 0.019). Multivariate analysis showed that high SUVmean-VAT was a significant factor for poor RFS and poor DMFS (p = 0.023 and 0.039, respectively). High SUVmax-tumor was significantly associated with short RFS (p = 0.0388). Tumors with a high SUV tended to have a short DMFS, although the difference was not significant (p = 0.0718). Our findings showed that upregulated glucose metabolism in the VAT measured using 18F-FDG PET/CT may be a prognostic biomarker for adverse outcomes in breast cancer. |
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| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T07:20:34Z |
| publishDate | 2022-12-01 |
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| series | Scientific Reports |
| spelling | doaj.art-c30117a11c864771bd2fa5f7c0c659ce2022-12-22T02:56:38ZengNature PortfolioScientific Reports2045-23222022-12-0112111110.1038/s41598-022-25540-418F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrenceHyun Jeong Kim0Dooreh Kim1Soong June Bae2Sung Gwe Ahn3Joon Jeong4Woo-Chan Park5Young Hoon Ryu6Tae Joo Jeon7Yangkyu Lee8Yoon Jin Cha9Chang Ik Yoon10Department of Nuclear Medicine, Yongin Severance Hospital, Yonsei University College of MedicineDivision of Breast Surgery, Department of Surgery, College of Medicine, Seoul St Mary’s Hospital, The Catholic University of KoreaDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDivision of Breast Surgery, Department of Surgery, College of Medicine, Seoul St Mary’s Hospital, The Catholic University of KoreaDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineInstitute for Breast Cancer Precision Medicine, Yonsei University College of MedicineInstitute for Breast Cancer Precision Medicine, Yonsei University College of MedicineDivision of Breast Surgery, Department of Surgery, College of Medicine, Seoul St Mary’s Hospital, The Catholic University of KoreaAbstract Glucose utilization by visceral adipose tissue (VAT) reflects inflammatory activity, which also promotes tumor growth and carcinogenesis. The effect of metabolically active VAT on survival outcomes in breast cancer is unknown. We investigated survival outcomes in patients with breast cancer based on the standardized uptake value (SUV) of VAT (SUVmean-VAT) using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). A total of 148 patients with breast cancer were divided into high- and low groups according to their SUVmean-VAT and SUVmax-tumor. Clinical characteristics and survival outcomes were compared between the groups. High SUVmean-VAT was associated with poor recurrence-free survival (RFS; hazard ratio [HR], 2.754; 95% confidence interval [CI], 1.090–6.958, p = 0.032) and distant metastasis-free survival (DMFS; HR, 3.500; 95% CI, 1.224–10.01, p = 0.019). Multivariate analysis showed that high SUVmean-VAT was a significant factor for poor RFS and poor DMFS (p = 0.023 and 0.039, respectively). High SUVmax-tumor was significantly associated with short RFS (p = 0.0388). Tumors with a high SUV tended to have a short DMFS, although the difference was not significant (p = 0.0718). Our findings showed that upregulated glucose metabolism in the VAT measured using 18F-FDG PET/CT may be a prognostic biomarker for adverse outcomes in breast cancer.https://doi.org/10.1038/s41598-022-25540-4 |
| spellingShingle | Hyun Jeong Kim Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Woo-Chan Park Young Hoon Ryu Tae Joo Jeon Yangkyu Lee Yoon Jin Cha Chang Ik Yoon 18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence Scientific Reports |
| title | 18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence |
| title_full | 18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence |
| title_fullStr | 18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence |
| title_full_unstemmed | 18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence |
| title_short | 18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence |
| title_sort | 18f fdg uptake of visceral adipose tissue on preoperative pet ct as a predictive marker for breast cancer recurrence |
| url | https://doi.org/10.1038/s41598-022-25540-4 |
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