To engage or not engage: Early incentive motivation prevents symptoms of chronic post-stroke depression – A longitudinal study
Background: Although post-stroke depression (PSD) is known to disrupt motor rehabilitation after stroke, PSD is often undertreated and its relationship with motor impairment remains poorly understood. Methods: In a longitudinal study design we investigated, which factors at the early post-acute stag...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158223000499 |
| _version_ | 1797869782164307968 |
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| author | Janusz L. Koob Shivakumar Viswanathan Maike Mustin Imon Mallick Sebastian Krick Gereon R. Fink Christian Grefkes Anne K. Rehme |
| author_facet | Janusz L. Koob Shivakumar Viswanathan Maike Mustin Imon Mallick Sebastian Krick Gereon R. Fink Christian Grefkes Anne K. Rehme |
| author_sort | Janusz L. Koob |
| collection | DOAJ |
| description | Background: Although post-stroke depression (PSD) is known to disrupt motor rehabilitation after stroke, PSD is often undertreated and its relationship with motor impairment remains poorly understood. Methods: In a longitudinal study design we investigated, which factors at the early post-acute stage may increase the risk for PSD symptoms. We were especially interested in whether interindividual differences in the motivational drive to engage in physically demanding tasks indicate PSD development in patients suffering from motor impairments. Accordingly, we used a monetary incentive grip force task where participants were asked to hold their grip force for high and low rewards at stake to maximize their monetary outcome. Individual grip force was normalized according to the maximal force prior to the experiment. Experimental data, depression, and motor impairment were assessed from 20 stroke patients (12 male; 7.7 ± 6.78 days post-stroke) with mild-to-moderate hand motor impairment and 24 age-matched healthy participants (12 male). Results: Both groups showed incentive motivation as indicated by stronger grip force for high versus low reward trials and the overall monetary outcome in the task. In stroke patients, severely impaired patients showed stronger incentive motivation, whereas early PSD symptoms were associated with reduced incentive motivation in the task. Larger lesions in corticostriatal tracts correlated with reduced incentive motivation. Importantly, chronic motivational deficits were preceded by initially reduced incentive motivation and larger corticostriatal lesions in the early stage post-stroke. Conclusions: More severe motor impairment motivates reward-dependent motor engagement, whereas PSD and corticostriatal lesions potentially disturb incentive motivational behavior, thereby increasing the risk of chronic motivational PSD symptoms. Acute interventions should address motivational aspects of behavior to improve motor rehabilitation post-stroke. |
| first_indexed | 2024-04-10T00:17:27Z |
| format | Article |
| id | doaj.art-c3027fdd6df0410986e15b1cdaa762a7 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-10T00:17:27Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-c3027fdd6df0410986e15b1cdaa762a72023-03-16T05:04:15ZengElsevierNeuroImage: Clinical2213-15822023-01-0137103360To engage or not engage: Early incentive motivation prevents symptoms of chronic post-stroke depression – A longitudinal studyJanusz L. Koob0Shivakumar Viswanathan1Maike Mustin2Imon Mallick3Sebastian Krick4Gereon R. Fink5Christian Grefkes6Anne K. Rehme7Department of Neurology, University Hospital Cologne, 50937 Cologne, Germany; Corresponding authors at: Department of Neurology, University Hospital Cologne, 50937 Cologne, Germany (J.L. Koob) and Department of Neurology, University Hospital Frankfurt, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany (C. Grefkes).Institute of Neuroscience and Medicine, Cognitive Neuroscience (INM-3), Forschungszentrum Jülich, 52425 Juelich, GermanyDepartment of Neurology, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Neurology, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Neurology, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Neurology, University Hospital Cologne, 50937 Cologne, Germany; Institute of Neuroscience and Medicine, Cognitive Neuroscience (INM-3), Forschungszentrum Jülich, 52425 Juelich, GermanyDepartment of Neurology, University Hospital Cologne, 50937 Cologne, Germany; Institute of Neuroscience and Medicine, Cognitive Neuroscience (INM-3), Forschungszentrum Jülich, 52425 Juelich, Germany; Department of Neurology, University Hospital Frankfurt, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany; Corresponding authors at: Department of Neurology, University Hospital Cologne, 50937 Cologne, Germany (J.L. Koob) and Department of Neurology, University Hospital Frankfurt, Goethe University Frankfurt, 60590 Frankfurt am Main, Germany (C. Grefkes).Department of Neurology, University Hospital Cologne, 50937 Cologne, GermanyBackground: Although post-stroke depression (PSD) is known to disrupt motor rehabilitation after stroke, PSD is often undertreated and its relationship with motor impairment remains poorly understood. Methods: In a longitudinal study design we investigated, which factors at the early post-acute stage may increase the risk for PSD symptoms. We were especially interested in whether interindividual differences in the motivational drive to engage in physically demanding tasks indicate PSD development in patients suffering from motor impairments. Accordingly, we used a monetary incentive grip force task where participants were asked to hold their grip force for high and low rewards at stake to maximize their monetary outcome. Individual grip force was normalized according to the maximal force prior to the experiment. Experimental data, depression, and motor impairment were assessed from 20 stroke patients (12 male; 7.7 ± 6.78 days post-stroke) with mild-to-moderate hand motor impairment and 24 age-matched healthy participants (12 male). Results: Both groups showed incentive motivation as indicated by stronger grip force for high versus low reward trials and the overall monetary outcome in the task. In stroke patients, severely impaired patients showed stronger incentive motivation, whereas early PSD symptoms were associated with reduced incentive motivation in the task. Larger lesions in corticostriatal tracts correlated with reduced incentive motivation. Importantly, chronic motivational deficits were preceded by initially reduced incentive motivation and larger corticostriatal lesions in the early stage post-stroke. Conclusions: More severe motor impairment motivates reward-dependent motor engagement, whereas PSD and corticostriatal lesions potentially disturb incentive motivational behavior, thereby increasing the risk of chronic motivational PSD symptoms. Acute interventions should address motivational aspects of behavior to improve motor rehabilitation post-stroke.http://www.sciencedirect.com/science/article/pii/S2213158223000499RewardMotor impairmentGrip forcePrognosisPSDCorticostriatal network lesions |
| spellingShingle | Janusz L. Koob Shivakumar Viswanathan Maike Mustin Imon Mallick Sebastian Krick Gereon R. Fink Christian Grefkes Anne K. Rehme To engage or not engage: Early incentive motivation prevents symptoms of chronic post-stroke depression – A longitudinal study NeuroImage: Clinical Reward Motor impairment Grip force Prognosis PSD Corticostriatal network lesions |
| title | To engage or not engage: Early incentive motivation prevents symptoms of chronic post-stroke depression – A longitudinal study |
| title_full | To engage or not engage: Early incentive motivation prevents symptoms of chronic post-stroke depression – A longitudinal study |
| title_fullStr | To engage or not engage: Early incentive motivation prevents symptoms of chronic post-stroke depression – A longitudinal study |
| title_full_unstemmed | To engage or not engage: Early incentive motivation prevents symptoms of chronic post-stroke depression – A longitudinal study |
| title_short | To engage or not engage: Early incentive motivation prevents symptoms of chronic post-stroke depression – A longitudinal study |
| title_sort | to engage or not engage early incentive motivation prevents symptoms of chronic post stroke depression a longitudinal study |
| topic | Reward Motor impairment Grip force Prognosis PSD Corticostriatal network lesions |
| url | http://www.sciencedirect.com/science/article/pii/S2213158223000499 |
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