Phenolic and flavonoid compounds extraction from Calophyllum inophyllum leaves
Calophyllum inophyllum has been known as a part of the mangrove forest area. This species is distributed primarily in the coastal regions of Indonesia and Africa. It is rich in bioactive compounds and has been used as a traditional medication. This work employed a single replicate of the one-factor-...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S187853522100681X |
| _version_ | 1818286688327172096 |
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| author | Safrina Hapsari Imelia Yohed Rachel Angie Kristianita Nurud Jadid Hakun Wirawasista Aparamarta Setiyo Gunawan |
| author_facet | Safrina Hapsari Imelia Yohed Rachel Angie Kristianita Nurud Jadid Hakun Wirawasista Aparamarta Setiyo Gunawan |
| author_sort | Safrina Hapsari |
| collection | DOAJ |
| description | Calophyllum inophyllum has been known as a part of the mangrove forest area. This species is distributed primarily in the coastal regions of Indonesia and Africa. It is rich in bioactive compounds and has been used as a traditional medication. This work employed a single replicate of the one-factor-at-a-time experiment method to investigate optimum conditions, which resulted in the highest TPC. The three factors studied were organic solvent type (acetone, ethanol, and methanol), organic solvent concentration in water (50–100%, v/v), and extraction temperature (30–60 °C). The extraction was conducted with the percolation method. The result shows that organic solvent type, organic solvent concentration in water, and extraction temperature significantly affect the TPC, TFC, and the yield of crude extract obtained. The highest TPC (289.12 mg GAE/g of the residue of C. inophyllum leaves) was achieved with 80% methanol in water at 30 °C for 48 h. Under this condition, TFC value of 410.4 mg QE/g of the residue of C. inophyllum leaves, the yield of 2.41%, and IC50 value of 0.054 µg/mL were achieved. Moreover, bis (2-ethylhexyl) phthalate was firstly detected in the extract. |
| first_indexed | 2024-12-13T01:28:34Z |
| format | Article |
| id | doaj.art-c3049d1849c24c74a5745fc5b207f6c9 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-13T01:28:34Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-c3049d1849c24c74a5745fc5b207f6c92022-12-22T00:04:04ZengElsevierArabian Journal of Chemistry1878-53522022-03-01153103666Phenolic and flavonoid compounds extraction from Calophyllum inophyllum leavesSafrina Hapsari0Imelia Yohed1Rachel Angie Kristianita2Nurud Jadid3Hakun Wirawasista Aparamarta4Setiyo Gunawan5Department of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, IndonesiaDepartment of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, IndonesiaDepartment of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, IndonesiaDepartment of Biology, Institut Teknologi Sepuluh Nopember, Surabaya 60111, IndonesiaDepartment of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, IndonesiaDepartment of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia; Corresponding author at: Department of Chemical Engineering, Faculty of Industrial Technology, Institut Teknologi Sepuluh Nopember, Keputih Sukolilo, Surabaya 60111, Indonesia.Calophyllum inophyllum has been known as a part of the mangrove forest area. This species is distributed primarily in the coastal regions of Indonesia and Africa. It is rich in bioactive compounds and has been used as a traditional medication. This work employed a single replicate of the one-factor-at-a-time experiment method to investigate optimum conditions, which resulted in the highest TPC. The three factors studied were organic solvent type (acetone, ethanol, and methanol), organic solvent concentration in water (50–100%, v/v), and extraction temperature (30–60 °C). The extraction was conducted with the percolation method. The result shows that organic solvent type, organic solvent concentration in water, and extraction temperature significantly affect the TPC, TFC, and the yield of crude extract obtained. The highest TPC (289.12 mg GAE/g of the residue of C. inophyllum leaves) was achieved with 80% methanol in water at 30 °C for 48 h. Under this condition, TFC value of 410.4 mg QE/g of the residue of C. inophyllum leaves, the yield of 2.41%, and IC50 value of 0.054 µg/mL were achieved. Moreover, bis (2-ethylhexyl) phthalate was firstly detected in the extract.http://www.sciencedirect.com/science/article/pii/S187853522100681XAntioxidant activityCalophyllum inophyllum leavesExtractionHealthTotal flavonoid contentTotal phenolic content |
| spellingShingle | Safrina Hapsari Imelia Yohed Rachel Angie Kristianita Nurud Jadid Hakun Wirawasista Aparamarta Setiyo Gunawan Phenolic and flavonoid compounds extraction from Calophyllum inophyllum leaves Arabian Journal of Chemistry Antioxidant activity Calophyllum inophyllum leaves Extraction Health Total flavonoid content Total phenolic content |
| title | Phenolic and flavonoid compounds extraction from Calophyllum inophyllum leaves |
| title_full | Phenolic and flavonoid compounds extraction from Calophyllum inophyllum leaves |
| title_fullStr | Phenolic and flavonoid compounds extraction from Calophyllum inophyllum leaves |
| title_full_unstemmed | Phenolic and flavonoid compounds extraction from Calophyllum inophyllum leaves |
| title_short | Phenolic and flavonoid compounds extraction from Calophyllum inophyllum leaves |
| title_sort | phenolic and flavonoid compounds extraction from calophyllum inophyllum leaves |
| topic | Antioxidant activity Calophyllum inophyllum leaves Extraction Health Total flavonoid content Total phenolic content |
| url | http://www.sciencedirect.com/science/article/pii/S187853522100681X |
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