The Contribution of Lysosomes to DNA Replication
Lysosomes, acidic, membrane-bound organelles, are not only the core of the cellular recycling machinery, but they also serve as signaling hubs regulating various metabolic pathways. Lysosomes maintain energy homeostasis and provide pivotal substrates for anabolic processes, such as DNA replication....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/5/1068 |
| _version_ | 1797535660776620032 |
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| author | Joanna Maria Merchut-Maya Apolinar Maya-Mendoza |
| author_facet | Joanna Maria Merchut-Maya Apolinar Maya-Mendoza |
| author_sort | Joanna Maria Merchut-Maya |
| collection | DOAJ |
| description | Lysosomes, acidic, membrane-bound organelles, are not only the core of the cellular recycling machinery, but they also serve as signaling hubs regulating various metabolic pathways. Lysosomes maintain energy homeostasis and provide pivotal substrates for anabolic processes, such as DNA replication. Every time the cell divides, its genome needs to be correctly duplicated; therefore, DNA replication requires rigorous regulation. Challenges that negatively affect DNA synthesis, such as nucleotide imbalance, result in replication stress with severe consequences for genome integrity. The lysosomal complex mTORC1 is directly involved in the synthesis of purines and pyrimidines to support DNA replication. Numerous drugs have been shown to target lysosomal function, opening an attractive avenue for new treatment strategies against various pathologies, including cancer. In this review, we focus on the interplay between lysosomal function and DNA replication through nucleic acid degradation and nucleotide biosynthesis and how these could be exploited for therapeutic purposes. |
| first_indexed | 2024-03-10T11:47:32Z |
| format | Article |
| id | doaj.art-c304ecfcb58e460ab97c483ea8812261 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:47:32Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c304ecfcb58e460ab97c483ea88122612023-11-21T17:58:33ZengMDPI AGCells2073-44092021-04-01105106810.3390/cells10051068The Contribution of Lysosomes to DNA ReplicationJoanna Maria Merchut-Maya0Apolinar Maya-Mendoza1DNA Replication and Cancer Group, Danish Cancer Society Research Center, DK-2100 Copenhagen, DenmarkDNA Replication and Cancer Group, Danish Cancer Society Research Center, DK-2100 Copenhagen, DenmarkLysosomes, acidic, membrane-bound organelles, are not only the core of the cellular recycling machinery, but they also serve as signaling hubs regulating various metabolic pathways. Lysosomes maintain energy homeostasis and provide pivotal substrates for anabolic processes, such as DNA replication. Every time the cell divides, its genome needs to be correctly duplicated; therefore, DNA replication requires rigorous regulation. Challenges that negatively affect DNA synthesis, such as nucleotide imbalance, result in replication stress with severe consequences for genome integrity. The lysosomal complex mTORC1 is directly involved in the synthesis of purines and pyrimidines to support DNA replication. Numerous drugs have been shown to target lysosomal function, opening an attractive avenue for new treatment strategies against various pathologies, including cancer. In this review, we focus on the interplay between lysosomal function and DNA replication through nucleic acid degradation and nucleotide biosynthesis and how these could be exploited for therapeutic purposes.https://www.mdpi.com/2073-4409/10/5/1068lysosomesautophagymTORC1DNA synthesiscancer |
| spellingShingle | Joanna Maria Merchut-Maya Apolinar Maya-Mendoza The Contribution of Lysosomes to DNA Replication Cells lysosomes autophagy mTORC1 DNA synthesis cancer |
| title | The Contribution of Lysosomes to DNA Replication |
| title_full | The Contribution of Lysosomes to DNA Replication |
| title_fullStr | The Contribution of Lysosomes to DNA Replication |
| title_full_unstemmed | The Contribution of Lysosomes to DNA Replication |
| title_short | The Contribution of Lysosomes to DNA Replication |
| title_sort | contribution of lysosomes to dna replication |
| topic | lysosomes autophagy mTORC1 DNA synthesis cancer |
| url | https://www.mdpi.com/2073-4409/10/5/1068 |
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