Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders
Skeletal muscle comprises the major organ system in our bodies and is the effector tissue for fundamental processes, such as movement, breathing and glucose homeostasis. However, muscle regeneration can be insufficient to repair major injuries or become exhausted by the ongoing fiber damage that occ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | All Life |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/26895293.2023.2207774 |
| _version_ | 1797401376764985344 |
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| author | Hyun-Jun Kim Da-Woon Jung Darren R. Williams |
| author_facet | Hyun-Jun Kim Da-Woon Jung Darren R. Williams |
| author_sort | Hyun-Jun Kim |
| collection | DOAJ |
| description | Skeletal muscle comprises the major organ system in our bodies and is the effector tissue for fundamental processes, such as movement, breathing and glucose homeostasis. However, muscle regeneration can be insufficient to repair major injuries or become exhausted by the ongoing fiber damage that occurs in muscular dystrophy. Cell therapy to provide a source of myogenic stem cells that repopulate the lost muscle fibers is an attractive option to treat skeletal muscle injury or dystrophy. Induced pluripotent stem cells (iPSCs) have the potential to be an ideal source of donor muscle cells. This review will discuss major research applications of iPSCs to facilitate skeletal muscle repair, which involve myogenic cell transplantation, in vitro modeling of normal and dystrophic muscle tissue, and drug screening protocols. Recent advances in these fields will be discussed in this review, such as the production of neuromuscular junctions between muscle fibers and motor neurons, along with an overview of the problems that currently prevent iPSCs from being a clinically valid source of transplantable skeletal muscle stem cells. Potential future applications of iPSCs to enhance skeletal muscle regeneration will also be discussed. |
| first_indexed | 2024-03-09T02:09:08Z |
| format | Article |
| id | doaj.art-c30635cf6c3549d5b92084cfb8680fb3 |
| institution | Directory Open Access Journal |
| issn | 2689-5307 |
| language | English |
| last_indexed | 2024-03-09T02:09:08Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj.art-c30635cf6c3549d5b92084cfb8680fb32023-12-07T15:12:04ZengTaylor & Francis GroupAll Life2689-53072023-12-0116110.1080/26895293.2023.22077742207774Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disordersHyun-Jun Kim0Da-Woon Jung1Darren R. Williams2New Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and TechnologyNew Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and TechnologyNew Drug Targets Laboratory, School of Life Sciences, Gwangju Institute of Science and TechnologySkeletal muscle comprises the major organ system in our bodies and is the effector tissue for fundamental processes, such as movement, breathing and glucose homeostasis. However, muscle regeneration can be insufficient to repair major injuries or become exhausted by the ongoing fiber damage that occurs in muscular dystrophy. Cell therapy to provide a source of myogenic stem cells that repopulate the lost muscle fibers is an attractive option to treat skeletal muscle injury or dystrophy. Induced pluripotent stem cells (iPSCs) have the potential to be an ideal source of donor muscle cells. This review will discuss major research applications of iPSCs to facilitate skeletal muscle repair, which involve myogenic cell transplantation, in vitro modeling of normal and dystrophic muscle tissue, and drug screening protocols. Recent advances in these fields will be discussed in this review, such as the production of neuromuscular junctions between muscle fibers and motor neurons, along with an overview of the problems that currently prevent iPSCs from being a clinically valid source of transplantable skeletal muscle stem cells. Potential future applications of iPSCs to enhance skeletal muscle regeneration will also be discussed.http://dx.doi.org/10.1080/26895293.2023.2207774induced pluripotent stem cellsipscsskeletal musclevolumetric muscle lossmuscular dystrophybiomaterials |
| spellingShingle | Hyun-Jun Kim Da-Woon Jung Darren R. Williams Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders All Life induced pluripotent stem cells ipscs skeletal muscle volumetric muscle loss muscular dystrophy biomaterials |
| title | Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders |
| title_full | Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders |
| title_fullStr | Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders |
| title_full_unstemmed | Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders |
| title_short | Keeping your strength up: induced pluripotent stem cell-based approaches for the treatment and investigation of skeletal muscle disorders |
| title_sort | keeping your strength up induced pluripotent stem cell based approaches for the treatment and investigation of skeletal muscle disorders |
| topic | induced pluripotent stem cells ipscs skeletal muscle volumetric muscle loss muscular dystrophy biomaterials |
| url | http://dx.doi.org/10.1080/26895293.2023.2207774 |
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