Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely applied in the treatment of inflammation, fever and for pain relief based on its efficacy in anti-inflammatory, anti-rheumatic, analgesic, antipyretic, and anticoagulation. Moreover, the relationship between NSAIDs and immune cells is quite i...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-12-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201027.pdf |
| _version_ | 1827390546434326528 |
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| author | YU Jing, LIU Ke, WANG Hai-yan, YAN Jun |
| author_facet | YU Jing, LIU Ke, WANG Hai-yan, YAN Jun |
| author_sort | YU Jing, LIU Ke, WANG Hai-yan, YAN Jun |
| collection | DOAJ |
| description | Non-steroidal anti-inflammatory drugs (NSAIDs) are widely applied in the treatment of inflammation, fever and for pain relief based on its efficacy in anti-inflammatory, anti-rheumatic, analgesic, antipyretic, and anticoagulation. Moreover, the relationship between NSAIDs and immune cells is quite important since. NSAIDs can negatively regulate B cell proliferation via inhibiting prostaglandin (PG), improve the imbalance of Th1/Th2 and immunologic derangement caused by Th17 differentiation, inhibit release of TNF-α by macrophages and decrease the level of tumor necrosis factor (TNF)-α, influence inflammation via controlling other inflammatory cytokines. In addition, the mechanism may be concerned with several signal pathways including PGE2 receptor 2 (PGE2-EP2), 5-hydroxytryptamine(5-HT), glucagon-like peptide-2 (GLP-2) and nuclear factor kappa-B-interleukin-6- signal transducer and activator of transcription 3 (NF-κB-IL-6-STAT3). Thus, it is necessary to further investigate the regulation and mechanism of NSAIDs on various immunocytes, potentially provide a new strategy to optimize immune funtions under trauma and disease. |
| first_indexed | 2024-03-08T16:54:14Z |
| format | Article |
| id | doaj.art-c3064879266940d792a105e086bba2ae |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:54:14Z |
| publishDate | 2021-12-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-c3064879266940d792a105e086bba2ae2024-01-05T03:07:37ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252021-12-01411218331837Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytesYU Jing, LIU Ke, WANG Hai-yan, YAN Jun01. Department of Special War Wound, State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery,Army Medical University, Chongqing 400042;;2. School of Life Science and Engineering, Southwest Jiaotong University,Chengdu 610031, ChinaNon-steroidal anti-inflammatory drugs (NSAIDs) are widely applied in the treatment of inflammation, fever and for pain relief based on its efficacy in anti-inflammatory, anti-rheumatic, analgesic, antipyretic, and anticoagulation. Moreover, the relationship between NSAIDs and immune cells is quite important since. NSAIDs can negatively regulate B cell proliferation via inhibiting prostaglandin (PG), improve the imbalance of Th1/Th2 and immunologic derangement caused by Th17 differentiation, inhibit release of TNF-α by macrophages and decrease the level of tumor necrosis factor (TNF)-α, influence inflammation via controlling other inflammatory cytokines. In addition, the mechanism may be concerned with several signal pathways including PGE2 receptor 2 (PGE2-EP2), 5-hydroxytryptamine(5-HT), glucagon-like peptide-2 (GLP-2) and nuclear factor kappa-B-interleukin-6- signal transducer and activator of transcription 3 (NF-κB-IL-6-STAT3). Thus, it is necessary to further investigate the regulation and mechanism of NSAIDs on various immunocytes, potentially provide a new strategy to optimize immune funtions under trauma and disease.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201027.pdfnon-steroidal anti-inflammatory drugs (nsaids)|regulation|immunocyte |
| spellingShingle | YU Jing, LIU Ke, WANG Hai-yan, YAN Jun Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes Jichu yixue yu linchuang non-steroidal anti-inflammatory drugs (nsaids)|regulation|immunocyte |
| title | Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes |
| title_full | Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes |
| title_fullStr | Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes |
| title_full_unstemmed | Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes |
| title_short | Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes |
| title_sort | research progress in regulation of non steroidal anti inflammatory drugs on immunocytes |
| topic | non-steroidal anti-inflammatory drugs (nsaids)|regulation|immunocyte |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201027.pdf |
| work_keys_str_mv | AT yujingliukewanghaiyanyanjun researchprogressinregulationofnonsteroidalantiinflammatorydrugsonimmunocytes |