Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Abstract Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lungs that is currently the fourth leading cause of death worldwide. Genetic factors account for only a small amount of COPD risk, but epigenetic mechanisms, including DNA methylation, have the potenti...

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Bibliographic Details
Main Authors: Rachel L. Clifford, Nick Fishbane, Jamie Patel, Julia L. MacIsaac, Lisa M. McEwen, Andrew J. Fisher, Corry-Anke Brandsma, Parameswaran Nair, Michael S. Kobor, Tillie-Louise Hackett, Alan J. Knox
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Fibroblasts
COPD
Airway
Parenchyma
Online Access:http://link.springer.com/article/10.1186/s13148-018-0464-5

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