Lack of Endothelial α1AMPK Reverses the Vascular Protective Effects of Exercise by Causing eNOS Uncoupling

Lack of Endothelial α1AMPK Reverses the Vascular Protective Effects of Exercise by Causing eNOS Uncoupling

Voluntary exercise training is an effective way to prevent cardiovascular disease, since it results in increased NO bioavailability and decreased reactive oxygen species (ROS) production. AMP-activated protein kinase (AMPK), especially its α1AMPK subunit, modulates ROS-dependent vascular homeostasis...

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Bibliographic Details
Main Authors: Thomas Jansen, Miroslava Kvandová, Isabella Schmal, Sanela Kalinovic, Paul Stamm, Marin Kuntic, Marc Foretz, Benoit Viollet, Andreas Daiber, Matthias Oelze, John F. Keaney, Thomas Münzel, Eberhard Schulz, Swenja Kröller-Schön
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
α1AMPK
endothelial cells
exercise training
reactive oxygen species
endothelial dysfunction
Online Access:https://www.mdpi.com/2076-3921/10/12/1974

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