External apical root resorption in orthodontic patients: molecular and genetic basis
External apical root resorption is one of the most deleterious complications after orthodontic treatment. Studies to explain the causal relationship between orthodontic tooth movement and external apical root resorption have been inconclusive till date. Individual variations in external apical root...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=8;spage=3872;epage=3882;aulast=Kalra |
| _version_ | 1818145742628323328 |
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| author | Shilpa Kalra Prateek Gupta Tulika Tripathi Priyank Rai |
| author_facet | Shilpa Kalra Prateek Gupta Tulika Tripathi Priyank Rai |
| author_sort | Shilpa Kalra |
| collection | DOAJ |
| description | External apical root resorption is one of the most deleterious complications after orthodontic treatment. Studies to explain the causal relationship between orthodontic tooth movement and external apical root resorption have been inconclusive till date. Individual variations in external apical root resorption sometimes overshadow the treatment related factors which indicate genetic predisposition and/or multifactorial etiology. Mechanism of root resorption is not completely understood. Inflammatory root resorption induced by orthodontic treatment is a part of process of elimination of hyaline zone. An imbalance between bone resorption and deposition may contribute to root resorption by the cementoclasts/osteoclasts. This narrative review article explains the molecular pathway involved in external apical root resorption and also role of various genes involved at different level. It also reviews the literature published during the past 20 years concerning the association studies linking EARR to genetic polymorphisms. This literature review provides an insight into genetic predisposition of external apical root resorption that can be used in orthodontic practice to enable 'high-risk' subjects to be identified on the basis of their genetic information before orthodontic treatment is initiated. |
| first_indexed | 2024-12-11T12:08:18Z |
| format | Article |
| id | doaj.art-c309bc2a2bac4a2a8985d3a34ef83df9 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-11T12:08:18Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-c309bc2a2bac4a2a8985d3a34ef83df92022-12-22T01:07:52ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632020-01-01983872388210.4103/jfmpc.jfmpc_802_20External apical root resorption in orthodontic patients: molecular and genetic basisShilpa KalraPrateek GuptaTulika TripathiPriyank RaiExternal apical root resorption is one of the most deleterious complications after orthodontic treatment. Studies to explain the causal relationship between orthodontic tooth movement and external apical root resorption have been inconclusive till date. Individual variations in external apical root resorption sometimes overshadow the treatment related factors which indicate genetic predisposition and/or multifactorial etiology. Mechanism of root resorption is not completely understood. Inflammatory root resorption induced by orthodontic treatment is a part of process of elimination of hyaline zone. An imbalance between bone resorption and deposition may contribute to root resorption by the cementoclasts/osteoclasts. This narrative review article explains the molecular pathway involved in external apical root resorption and also role of various genes involved at different level. It also reviews the literature published during the past 20 years concerning the association studies linking EARR to genetic polymorphisms. This literature review provides an insight into genetic predisposition of external apical root resorption that can be used in orthodontic practice to enable 'high-risk' subjects to be identified on the basis of their genetic information before orthodontic treatment is initiated.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=8;spage=3872;epage=3882;aulast=Kalraetiologyexternal apical root resorptiongenetic polymorphism |
| spellingShingle | Shilpa Kalra Prateek Gupta Tulika Tripathi Priyank Rai External apical root resorption in orthodontic patients: molecular and genetic basis Journal of Family Medicine and Primary Care etiology external apical root resorption genetic polymorphism |
| title | External apical root resorption in orthodontic patients: molecular and genetic basis |
| title_full | External apical root resorption in orthodontic patients: molecular and genetic basis |
| title_fullStr | External apical root resorption in orthodontic patients: molecular and genetic basis |
| title_full_unstemmed | External apical root resorption in orthodontic patients: molecular and genetic basis |
| title_short | External apical root resorption in orthodontic patients: molecular and genetic basis |
| title_sort | external apical root resorption in orthodontic patients molecular and genetic basis |
| topic | etiology external apical root resorption genetic polymorphism |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=8;spage=3872;epage=3882;aulast=Kalra |
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