Current status and outcomes in heart transplantation: a narrative review
The first human heart transplantation was performed by Christian Barnard in 1967. While the technical aspect had been worked out, allograft rejection was a major limitation in the early days of heart transplant. The discovery of cyclosporine revolutionized the field and led to the modern era of t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-01-01
|
| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://article.imrpress.com/journal/RCM/23/1/10.31083/j.rcm2301011/2153-8174-23-1-011.pdf |
| _version_ | 1828429168534093824 |
|---|---|
| author | Morcos A. Awad Aakash Shah Bartley P. Griffith |
| author_facet | Morcos A. Awad Aakash Shah Bartley P. Griffith |
| author_sort | Morcos A. Awad |
| collection | DOAJ |
| description | The first human heart transplantation was performed by Christian Barnard in
1967. While the technical aspect had been worked out, allograft rejection was a
major limitation in the early days of heart transplant. The discovery of
cyclosporine revolutionized the field and led to the modern era of transplant.
Heart transplantation now offers the best survival benefit for patients with
end-stage heart failure with a median survival over 12 years. However, there are
still limitations including the impact of limited availability of graft, graft
dysfunction, and rejection, and long-term non-cardiac complications. This review
serves as an update on the short- and long-term outcomes following heart
transplantation focusing on the new donor allocation system, efforts to expand
the donor pool, primary graft dysfunction, acute cellular and antibody-mediated
rejection, cardiac allograft vasculopathy, and post-transplant malignancy and
renal dysfunction. |
| first_indexed | 2024-12-10T17:29:04Z |
| format | Article |
| id | doaj.art-c30e26f7c3a8473287d206a4f8472482 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-12-10T17:29:04Z |
| publishDate | 2022-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-c30e26f7c3a8473287d206a4f84724822022-12-22T01:39:44ZengIMR PressReviews in Cardiovascular Medicine1530-65502022-01-0123101110.31083/j.rcm2301011S1530-6550(22)00298-8Current status and outcomes in heart transplantation: a narrative reviewMorcos A. Awad0Aakash Shah1Bartley P. Griffith2Department of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Surgery, Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USAThe first human heart transplantation was performed by Christian Barnard in 1967. While the technical aspect had been worked out, allograft rejection was a major limitation in the early days of heart transplant. The discovery of cyclosporine revolutionized the field and led to the modern era of transplant. Heart transplantation now offers the best survival benefit for patients with end-stage heart failure with a median survival over 12 years. However, there are still limitations including the impact of limited availability of graft, graft dysfunction, and rejection, and long-term non-cardiac complications. This review serves as an update on the short- and long-term outcomes following heart transplantation focusing on the new donor allocation system, efforts to expand the donor pool, primary graft dysfunction, acute cellular and antibody-mediated rejection, cardiac allograft vasculopathy, and post-transplant malignancy and renal dysfunction.https://article.imrpress.com/journal/RCM/23/1/10.31083/j.rcm2301011/2153-8174-23-1-011.pdfheart transplantationdonation after cardiac deathhepatitis c virus donationdonor heart allocation systemimmunosuppression |
| spellingShingle | Morcos A. Awad Aakash Shah Bartley P. Griffith Current status and outcomes in heart transplantation: a narrative review Reviews in Cardiovascular Medicine heart transplantation donation after cardiac death hepatitis c virus donation donor heart allocation system immunosuppression |
| title | Current status and outcomes in heart transplantation: a narrative review |
| title_full | Current status and outcomes in heart transplantation: a narrative review |
| title_fullStr | Current status and outcomes in heart transplantation: a narrative review |
| title_full_unstemmed | Current status and outcomes in heart transplantation: a narrative review |
| title_short | Current status and outcomes in heart transplantation: a narrative review |
| title_sort | current status and outcomes in heart transplantation a narrative review |
| topic | heart transplantation donation after cardiac death hepatitis c virus donation donor heart allocation system immunosuppression |
| url | https://article.imrpress.com/journal/RCM/23/1/10.31083/j.rcm2301011/2153-8174-23-1-011.pdf |
| work_keys_str_mv | AT morcosaawad currentstatusandoutcomesinhearttransplantationanarrativereview AT aakashshah currentstatusandoutcomesinhearttransplantationanarrativereview AT bartleypgriffith currentstatusandoutcomesinhearttransplantationanarrativereview |