AsKC11, a Kunitz Peptide from <i>Anemonia sulcata</i>, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels

AsKC11, a Kunitz Peptide from <i>Anemonia sulcata</i>, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels

(1) Background: G protein-coupled inward-rectifier potassium (GIRK) channels, especially neuronal GIRK1/2 channels, have been the focus of intense research interest for developing drugs against brain diseases. In this context, venom peptides that selectively activate GIRK channels can be seen as a n...

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Bibliographic Details
Main Authors: Dongchen An, Ernesto Lopes Pinheiro-Junior, László Béress, Irina Gladkikh, Elena Leychenko, Eivind A. B. Undheim, Steve Peigneur, Jan Tytgat
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Marine Drugs
Subjects:
sea anemone venom
AsKC11
GIRK1/2
potassium channels
brain diseases
Online Access:https://www.mdpi.com/1660-3397/20/2/140

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