The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort
IntroductionThe 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. We aimed to assess the associations of the...
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1291020/full |
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| author | Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Tin Oreskovic Sinclair Carr Sinclair Carr Keren Papier Megan Conroy Jasper R. Senff Jasper R. Senff Jasper R. Senff Jasper R. Senff Jasper R. Senff Zeina Chemali Zeina Chemali Zeina Chemali Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Livia Parodi Livia Parodi Livia Parodi Livia Parodi Ernst Mayerhofer Ernst Mayerhofer Ernst Mayerhofer Ernst Mayerhofer Sandro Marini Sandro Marini Sandro Marini Sandro Marini Courtney Nunley Amy Newhouse Amy Newhouse Amy Newhouse An Ouyang An Ouyang H. Bart Brouwers Brandon Westover Brandon Westover Brandon Westover Cyprien Rivier Guido Falcone Virginia Howard George Howard Aleksandra Pikula Aleksandra Pikula Aleksandra Pikula Sarah Ibrahim Sarah Ibrahim Sarah Ibrahim Kevin N. Sheth Nirupama Yechoor Nirupama Yechoor Nirupama Yechoor Nirupama Yechoor Ronald M. Lazar Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Rudolph E. Tanzi Gregory Fricchione Gregory Fricchione Thomas Littlejohns Jonathan Rosand Jonathan Rosand Jonathan Rosand Jonathan Rosand |
| author_facet | Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Tin Oreskovic Sinclair Carr Sinclair Carr Keren Papier Megan Conroy Jasper R. Senff Jasper R. Senff Jasper R. Senff Jasper R. Senff Jasper R. Senff Zeina Chemali Zeina Chemali Zeina Chemali Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Livia Parodi Livia Parodi Livia Parodi Livia Parodi Ernst Mayerhofer Ernst Mayerhofer Ernst Mayerhofer Ernst Mayerhofer Sandro Marini Sandro Marini Sandro Marini Sandro Marini Courtney Nunley Amy Newhouse Amy Newhouse Amy Newhouse An Ouyang An Ouyang H. Bart Brouwers Brandon Westover Brandon Westover Brandon Westover Cyprien Rivier Guido Falcone Virginia Howard George Howard Aleksandra Pikula Aleksandra Pikula Aleksandra Pikula Sarah Ibrahim Sarah Ibrahim Sarah Ibrahim Kevin N. Sheth Nirupama Yechoor Nirupama Yechoor Nirupama Yechoor Nirupama Yechoor Ronald M. Lazar Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Rudolph E. Tanzi Gregory Fricchione Gregory Fricchione Thomas Littlejohns Jonathan Rosand Jonathan Rosand Jonathan Rosand Jonathan Rosand |
| author_sort | Sanjula D. Singh |
| collection | DOAJ |
| description | IntroductionThe 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. We aimed to assess the associations of the BCS with risk of incident dementia and stroke.MethodsThe BCS was derived from the United Kingdom Biobank (UKB) baseline evaluation for participants aged 40–69 years, recruited between 2006–2010. Associations of BCS and risk of subsequent incident dementia and stroke were estimated using Cox proportional hazard regressions, adjusted for sex assigned at birth and stratified by age groups at baseline.ResultsThe BCS (median: 12; IQR:11–14) was derived for 398,990 UKB participants (mean age: 57; females: 54%). There were 5,354 incident cases of dementia and 7,259 incident cases of stroke recorded during a median follow-up of 12.5 years. A five-point higher BCS at baseline was associated with a 59% (95%CI: 40-72%) lower risk of dementia among participants aged <50. Among those aged 50–59, the figure was 32% (95%CI: 20-42%) and 8% (95%CI: 2-14%) for those aged >59 years. A five-point higher BCS was associated with a 48% (95%CI: 39-56%) lower risk of stroke among participants aged <50, 52% (95%CI, 47-56%) among those aged 50–59, and 33% (95%CI, 29-37%) among those aged >59.DiscussionThe BCS has clinically relevant and statistically significant associations with risk of dementia and stroke in approximately 0.4 million UK people. Future research includes investigating the feasibility, adaptability and implementation of the BCS for patients and providers worldwide. |
| first_indexed | 2024-03-09T10:43:53Z |
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| id | doaj.art-c30fa6ef439248eb9bb5d0fe78cbed43 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-09T10:43:53Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-c30fa6ef439248eb9bb5d0fe78cbed432023-12-01T12:07:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-12-011410.3389/fneur.2023.12910201291020The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohortSanjula D. Singh0Sanjula D. Singh1Sanjula D. Singh2Sanjula D. Singh3Sanjula D. Singh4Tin Oreskovic5Sinclair Carr6Sinclair Carr7Keren Papier8Megan Conroy9Jasper R. Senff10Jasper R. Senff11Jasper R. Senff12Jasper R. Senff13Jasper R. Senff14Zeina Chemali15Zeina Chemali16Zeina Chemali17Leidys Gutierrez-Martinez18Leidys Gutierrez-Martinez19Leidys Gutierrez-Martinez20Leidys Gutierrez-Martinez21Livia Parodi22Livia Parodi23Livia Parodi24Livia Parodi25Ernst Mayerhofer26Ernst Mayerhofer27Ernst Mayerhofer28Ernst Mayerhofer29Sandro Marini30Sandro Marini31Sandro Marini32Sandro Marini33Courtney Nunley34Amy Newhouse35Amy Newhouse36Amy Newhouse37An Ouyang38An Ouyang39H. Bart Brouwers40Brandon Westover41Brandon Westover42Brandon Westover43Cyprien Rivier44Guido Falcone45Virginia Howard46George Howard47Aleksandra Pikula48Aleksandra Pikula49Aleksandra Pikula50Sarah Ibrahim51Sarah Ibrahim52Sarah Ibrahim53Kevin N. Sheth54Nirupama Yechoor55Nirupama Yechoor56Nirupama Yechoor57Nirupama Yechoor58Ronald M. Lazar59Christopher D. Anderson60Christopher D. Anderson61Christopher D. Anderson62Christopher D. Anderson63Christopher D. Anderson64Rudolph E. Tanzi65Gregory Fricchione66Gregory Fricchione67Thomas Littlejohns68Jonathan Rosand69Jonathan Rosand70Jonathan Rosand71Jonathan Rosand72Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesNuffield Department of Population Health, University of Oxford, Oxford, United KingdomDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United StatesNuffield Department of Population Health, University of Oxford, Oxford, United KingdomInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA, United StatesDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, United StatesNuffield Department of Population Health, University of Oxford, Oxford, United KingdomNuffield Department of Population Health, University of Oxford, Oxford, United KingdomHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, NetherlandsHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesDivision of Neuropsychiatry, Massachusetts General Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDivision of Neuropsychiatry, Massachusetts General Hospital, Boston, MA, United States0Department of Medicine, Massachusetts General Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, NetherlandsHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United States1Department of Neurology, Yale School of Medicine, New Haven, CT, United States1Department of Neurology, Yale School of Medicine, New Haven, CT, United States2Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States2Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States3Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada4Krembil Brain Institute, Toronto, ON, Canada5Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada3Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada4Krembil Brain Institute, Toronto, ON, Canada5Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada1Department of Neurology, Yale School of Medicine, New Haven, CT, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States6McKnight Brain Institute, Department of Neurology, School of Medicine, University of Alabama School of Medicine, Birmingham, AL, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United States7Department of Neurology, Brigham and Women’s Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United States8Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, MA, United StatesNuffield Department of Population Health, University of Oxford, Oxford, United KingdomHenry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United StatesBroad Institute of MIT and Harvard, Cambridge, MA, United StatesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, United StatesIntroductionThe 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. We aimed to assess the associations of the BCS with risk of incident dementia and stroke.MethodsThe BCS was derived from the United Kingdom Biobank (UKB) baseline evaluation for participants aged 40–69 years, recruited between 2006–2010. Associations of BCS and risk of subsequent incident dementia and stroke were estimated using Cox proportional hazard regressions, adjusted for sex assigned at birth and stratified by age groups at baseline.ResultsThe BCS (median: 12; IQR:11–14) was derived for 398,990 UKB participants (mean age: 57; females: 54%). There were 5,354 incident cases of dementia and 7,259 incident cases of stroke recorded during a median follow-up of 12.5 years. A five-point higher BCS at baseline was associated with a 59% (95%CI: 40-72%) lower risk of dementia among participants aged <50. Among those aged 50–59, the figure was 32% (95%CI: 20-42%) and 8% (95%CI: 2-14%) for those aged >59 years. A five-point higher BCS was associated with a 48% (95%CI: 39-56%) lower risk of stroke among participants aged <50, 52% (95%CI, 47-56%) among those aged 50–59, and 33% (95%CI, 29-37%) among those aged >59.DiscussionThe BCS has clinically relevant and statistically significant associations with risk of dementia and stroke in approximately 0.4 million UK people. Future research includes investigating the feasibility, adaptability and implementation of the BCS for patients and providers worldwide.https://www.frontiersin.org/articles/10.3389/fneur.2023.1291020/fullBrain Care Scorebrain healthpreventionrisk factorsUK Biobank (UKB)stroke |
| spellingShingle | Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Sanjula D. Singh Tin Oreskovic Sinclair Carr Sinclair Carr Keren Papier Megan Conroy Jasper R. Senff Jasper R. Senff Jasper R. Senff Jasper R. Senff Jasper R. Senff Zeina Chemali Zeina Chemali Zeina Chemali Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Leidys Gutierrez-Martinez Livia Parodi Livia Parodi Livia Parodi Livia Parodi Ernst Mayerhofer Ernst Mayerhofer Ernst Mayerhofer Ernst Mayerhofer Sandro Marini Sandro Marini Sandro Marini Sandro Marini Courtney Nunley Amy Newhouse Amy Newhouse Amy Newhouse An Ouyang An Ouyang H. Bart Brouwers Brandon Westover Brandon Westover Brandon Westover Cyprien Rivier Guido Falcone Virginia Howard George Howard Aleksandra Pikula Aleksandra Pikula Aleksandra Pikula Sarah Ibrahim Sarah Ibrahim Sarah Ibrahim Kevin N. Sheth Nirupama Yechoor Nirupama Yechoor Nirupama Yechoor Nirupama Yechoor Ronald M. Lazar Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Christopher D. Anderson Rudolph E. Tanzi Gregory Fricchione Gregory Fricchione Thomas Littlejohns Jonathan Rosand Jonathan Rosand Jonathan Rosand Jonathan Rosand The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort Frontiers in Neurology Brain Care Score brain health prevention risk factors UK Biobank (UKB) stroke |
| title | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
| title_full | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
| title_fullStr | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
| title_full_unstemmed | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
| title_short | The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort |
| title_sort | predictive validity of a brain care score for dementia and stroke data from the uk biobank cohort |
| topic | Brain Care Score brain health prevention risk factors UK Biobank (UKB) stroke |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1291020/full |
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predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT hbartbrouwers predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT brandonwestover predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT brandonwestover predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT brandonwestover predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT cyprienrivier predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT guidofalcone predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT virginiahoward predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT georgehoward predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT aleksandrapikula predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT aleksandrapikula predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT aleksandrapikula predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT sarahibrahim predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT sarahibrahim predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT sarahibrahim predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT kevinnsheth predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT nirupamayechoor predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT nirupamayechoor predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT nirupamayechoor predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT nirupamayechoor predictivevalidityofabraincarescorefordementiaandstrokedatafromtheukbiobankcohort AT ronaldmlazar 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